Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 6/20 | 0.59 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | WNT3 | P56703 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617958 | 0.93 | SFRP1 (0.51) | SFRP1BRD4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4618967 | 0.88 | SFRP1 (0.61) | SFRP1BRD4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4619001 | 0.84 | SFRP1 (0.41) | SFRP1BRD4ALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL4618493 | 0.83 | SFRP1 (0.47) | SFRP1BRD4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6101508 | 0.82 | SFRP1 (0.52) | SFRP1ALDH1A1SMN1; SMN2L3MBTL1WNT3 | |
| SCHEMBL4616759 | 0.82 | GBA1 (0.48) | SFRP1ALDH1A1SMN1; SMN2L3MBTL1CNR2 | |
| SCHEMBL17205770 | 0.81 | GBA1 (0.55) | BRD4ALDH1A1SMN1; SMN2MAPK1NPC1 | |
| SCHEMBL4616479 | 0.81 | SFRP1 (0.74) | SFRP1ALDH1A1SMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL4617455 | 0.81 | SFRP1 (0.46) | SFRP1BRD4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4617904 | 0.80 | CNR2 (0.45) | SFRP1CNR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | SFRP1 1/4885BRD4 2225/4885ALDH1A1 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.