Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749 | 0.81 | HDAC1 (0.49) | GPR119GAAHDAC1ALDH1A1NPC1 | |
| SCHEMBL6234 | 0.78 | NAMPT (0.52) | GPR119CYP17A1NAMPTRAB9ACYP3A4 | |
| SCHEMBL6167 | 0.78 | ADRB2 (0.53) | GPR119GAACYP17A1HDAC1L3MBTL1 | |
| SCHEMBL6447258 | 0.78 | HDAC1 (0.52) | GAACYP17A1BCL2HDAC1CA12 | |
| SCHEMBL17963188 | 0.77 | CYP17A1 (0.53) | GPR119GAACYP17A1NAMPTL3MBTL1 | |
| SCHEMBL5749 | 0.77 | CYP17A1 (0.44) | GAACYP17A1NAMPTL3MBTL1RAB9A | |
| SCHEMBL6445761 | 0.77 | ESRRG (0.55) | GAANAMPTL3MBTL1CA12CA1 | |
| SCHEMBL9971059 | 0.76 | GAA (0.51) | GAANAMPTL3MBTL1CA12CA1 | |
| SCHEMBL6236607 | 0.76 | GAA (0.51) | GAAL3MBTL1CA12CA1CA7 | |
| SCHEMBL13903558 | 0.74 | ESRRG (0.60) | GAAL3MBTL1CA1HDAC6ESRRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1310905-C | Antivirally active heterocyclic azahexane derivatives | NOVARTIS AG (CH) | 2007-04-18 | — | — | CN | disclosed |
| CN-1616453-A | Antivirally active heterocyclic azahexane derivatives | NOVARTIS AG (CH) | 2005-05-18 | — | — | CN | disclosed |
| CN-1193010-C | Heterocyclic azahexane derivatives with antiviral activity | NOVARTIS AG (CH) | 2005-03-16 | — | — | CN | disclosed |
| EP-0900210-B1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | NOVARTIS AG (CH) | 2005-02-09 | — | — | EP | disclosed |
| CN-1082508-C | Heterocyclic azahexane derivatives with antiviral activity | NOVARTIS AG (CH) | 2002-04-10 | — | — | CN | disclosed |
| CN-1319587-A | Heterocyclic azahexane derivatives with antiviral activity | NOVARTIS AG (CH) | 2001-10-31 | — | — | CN | disclosed |
| US-6300519-B1 | REACTING HYDRAZINE DERIVATIVE WITH EPOXIDE COMPOUND | NOVARTIS FINANCE CORPORATION | 2001-10-09 | — | — | US | disclosed |
| US-6166004-A | Combinations of HIV protease inhibitors with reverse transcriptase inhibitors | NOVARTIS FINANCE CORPORATION (US) | 2000-12-26 | — | — | US | disclosed |
| US-6110946-A | AN ENZYME INHIBITORS OF RETROVIRAL ASPARTATE PROTEASE FOR THE TREATMENT OF AIDS | NOVARTIS FINANCE CORPORATION (US) | 2000-08-29 | — | — | US | disclosed |
| CN-1216539-A | Heterocyclic azahexane derivatives with antiviral activity | NOVARTIS AG (CH) | 1999-05-12 | — | — | CN | disclosed |
| EP-0900210-A1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | Novartis AG (CH) | 1999-03-10 | — | — | EP | disclosed |
| US-5849911-A | Antivirally active heterocyclic azahexane derivatives | NOVARTIS FINANCE CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| WO-1997040029-A1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | NOVARTIS AG (CH) | 1997-10-30 | — | — | WO | disclosed |