Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30637051 | 0.84 | TRPV1 (0.44) | CYP17A1NAMPTCYP2D6CHRM4GAA | |
| SCHEMBL6692 | 0.84 | TRPV1 (0.44) | CYP17A1NAMPTCYP2D6CHRM4GAA | |
| SCHEMBL6234 | 0.82 | NAMPT (0.52) | CYP17A1NAMPTWNT3ARAB9ACYP3A4 | |
| SCHEMBL17963188 | 0.79 | CYP17A1 (0.53) | CYP17A1NAMPTGAARAB9AL3MBTL1 | |
| SCHEMBL23081593 | 0.78 | HDAC3 (0.42) | CYP17A1NAMPTCYP2C9GAARAB9A | |
| SCHEMBL30525777 | 0.78 | HDAC3 (0.42) | CYP17A1NAMPTCYP2C9GAARAB9A | |
| SCHEMBL9439389 | 0.77 | CYP3A4 (0.59) | NAMPTCYP2D6CYP2C9GAARAB9A | |
| SCHEMBL6167 | 0.77 | ADRB2 (0.53) | CYP17A1GAAL3MBTL1 | |
| SCHEMBL6103 | 0.77 | GPR119 (0.42) | CYP17A1NAMPTGAARAB9AL3MBTL1 | |
| SCHEMBL6447258 | 0.77 | HDAC1 (0.52) | CYP17A1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1310905-C | Antivirally active heterocyclic azahexane derivatives | NOVARTIS AG (CH) | 2007-04-18 | — | — | CN | disclosed |
| CN-1616453-A | Antivirally active heterocyclic azahexane derivatives | NOVARTIS AG (CH) | 2005-05-18 | — | — | CN | disclosed |
| CN-1193010-C | Heterocyclic azahexane derivatives with antiviral activity | NOVARTIS AG (CH) | 2005-03-16 | — | — | CN | disclosed |
| EP-0900210-B1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | NOVARTIS AG (CH) | 2005-02-09 | — | — | EP | disclosed |
| CN-1082508-C | Heterocyclic azahexane derivatives with antiviral activity | NOVARTIS AG (CH) | 2002-04-10 | — | — | CN | disclosed |
| CN-1319587-A | Heterocyclic azahexane derivatives with antiviral activity | NOVARTIS AG (CH) | 2001-10-31 | — | — | CN | disclosed |
| US-6300519-B1 | REACTING HYDRAZINE DERIVATIVE WITH EPOXIDE COMPOUND | NOVARTIS FINANCE CORPORATION | 2001-10-09 | — | — | US | disclosed |
| US-6166004-A | Combinations of HIV protease inhibitors with reverse transcriptase inhibitors | NOVARTIS FINANCE CORPORATION (US) | 2000-12-26 | — | — | US | disclosed |
| US-6110946-A | AN ENZYME INHIBITORS OF RETROVIRAL ASPARTATE PROTEASE FOR THE TREATMENT OF AIDS | NOVARTIS FINANCE CORPORATION (US) | 2000-08-29 | — | — | US | disclosed |
| CN-1216539-A | Heterocyclic azahexane derivatives with antiviral activity | NOVARTIS AG (CH) | 1999-05-12 | — | — | CN | disclosed |
| EP-0900210-A1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | Novartis AG (CH) | 1999-03-10 | — | — | EP | disclosed |
| US-5849911-A | Antivirally active heterocyclic azahexane derivatives | NOVARTIS FINANCE CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| WO-1997040029-A1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | NOVARTIS AG (CH) | 1997-10-30 | — | — | WO | disclosed |