Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4616978 | 0.93 | SFRP1 (0.75) | SFRP1ALDH1A1POLB | |
| SCHEMBL4616503 | 0.86 | SFRP1 (0.86) | SFRP1ALDH1A1TP53GAATDP1 | |
| SCHEMBL4616698 | 0.85 | SFRP1 (0.72) | SFRP1ALDH1A1POLB | |
| SCHEMBL4618982 | 0.85 | SFRP1 (0.70) | SFRP1ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL4616141 | 0.84 | SFRP1 (1.00) | SFRP1ALDH1A1GAAKMT2A | |
| SCHEMBL4618064 | 0.84 | SFRP1 (0.71) | SFRP1ALDH1A1POLB | |
| SCHEMBL4617084 | 0.83 | SFRP1 (0.81) | SFRP1ALDH1A1 | |
| SCHEMBL4618969 | 0.83 | SFRP1 (0.68) | SFRP1ALDH1A1 | |
| SCHEMBL4618047 | 0.81 | SFRP1 (0.67) | SFRP1ALDH1A1GAAPOLBMEN1 | |
| SCHEMBL4618852 | 0.81 | SFRP1 (1.00) | SFRP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | SFRP1 1/4885ALDH1A1 1865/4885TP53 4653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.