Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.54 |
| ▸ | HTR1A | P08908 | 18/20 | 0.54 |
| ▸ | HTR2A | P28223 | 18/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6105551 | 0.94 | HTR1A (0.55) | DRD2HTR1AHTR2ASLC6A4DRD4 | |
| SCHEMBL6101535 | 0.89 | DRD2 (0.59) | DRD2HTR1AHTR2ASLC6A4DRD4 | |
| SCHEMBL6101800 | 0.88 | HTR1A (0.56) | DRD2HTR1AHTR2ASLC6A4KCNH2 | |
| SCHEMBL6102727 | 0.83 | HTR1A (0.56) | DRD2HTR1AHTR2ASLC6A4 | |
| SCHEMBL5373877 | 0.83 | HTR1A (0.68) | DRD2HTR1AHTR2ASLC6A4KCNH2 | |
| SCHEMBL6104010 | 0.81 | DRD2 (0.72) | DRD2HTR1AHTR2A | |
| SCHEMBL5369417 | 0.81 | HTR1A (0.64) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL5364650 | 0.81 | DRD2 (0.72) | DRD2HTR1AHTR2ASLC6A4DRD4 | |
| SCHEMBL5371781 | 0.80 | DRD2 (0.69) | DRD2HTR1AHTR2ASLC6A4DRD4 | |
| SCHEMBL5374936 | 0.79 | DRD2 (0.66) | DRD2HTR1AHTR2ASLC6A4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006090272-A1 | ISOQUINOLINE [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2006-08-31 | — | — | WO | claimed |
| WO-2006090272-A1 | ISOQUINOLINE [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2006-08-31 | — | — | WO | disclosed |