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SCHEMBL6103642

SCHEMBL6103642

CC(C)C(=O)N1CCC[C@@H]1C(=O)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 20/20 1.00
▸ WNT3 P56703 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4782019 1.00 SFRP1 (1.00) SFRP1WNT3
SCHEMBL6101814 0.91 SFRP1 (1.00) SFRP1WNT3
SCHEMBL4780818 0.91 SFRP1 (1.00) SFRP1WNT3
SCHEMBL4616363 0.91 SFRP1 (0.87) SFRP1WNT3
SCHEMBL4615676 0.91 SFRP1 (0.87) SFRP1WNT3
SCHEMBL6102504 0.90 SFRP1 (1.00) SFRP1WNT3
SCHEMBL6103652 0.90 SFRP1 (1.00) SFRP1WNT3
SCHEMBL6103648 0.90 SFRP1 (1.00) SFRP1WNT3
SCHEMBL6102172 0.89 SFRP1 (1.00) SFRP1WNT3
SCHEMBL6102960 0.89 SFRP1 (1.00) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060276464-A1 Diarylsulfone sulfonamides and use thereof WYETH (US) 2006-12-07 — — US claimed
US-20060276464-A1 Diarylsulfone sulfonamides and use thereof WYETH (US) 2006-12-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276464-A1 Diarylsulfone sulfonamides and use thereof SFRP1, SOS1, FZD7 SFRP1 1/4885WNT3 346/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.