SCHEMBL610783

SCHEMBL610783

O=C(c1ccc(O)cc1)c1ccc(Cl)cc1Cl

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 1/20 0.72
MAPT P10636 4/20 0.66
RAB9A P51151 3/20 0.66
MAPK1 P28482 2/20 0.62
SMN1; SMN2 Q16637 3/20 0.55
TSHR P16473 1/20 0.55
CASP1 P29466 1/20 0.55
HTT P42858 3/20 0.53
POLB P06746 2/20 0.51
MEN1 O00255 1/20 0.51
CYP2C9 P11712 1/20 0.51
KMT2A Q03164 1/20 0.51
LMNA P02545 2/20 0.50
ESR1 P03372 1/20 0.50
ESR2 Q92731 1/20 0.50
PKM P14618 1/20 0.50
HPGD P15428 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HIF1A Q16665 1/20 0.50
NPC1 O15118 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9496067 0.90 SRD5A2 (0.79) SRD5A2MAPTRAB9AMAPK1SMN1; SMN2
SCHEMBL1758244 0.89 SRD5A2 (0.56) SRD5A2MAPTRAB9AMAPK1SMN1; SMN2
SCHEMBL612249 0.85 MAPK1 (0.62) SRD5A2MAPTRAB9AMAPK1HTT
SCHEMBL8437570 0.85 SRD5A2 (0.96) SRD5A2MAPTRAB9AMAPK1SMN1; SMN2
SCHEMBL8684116 0.85 SRD5A2 (0.72) SRD5A2MAPTRAB9AMAPK1SMN1; SMN2
SCHEMBL10775755 0.84 MAPK1 (0.60) SRD5A2MAPTRAB9AMAPK1SMN1; SMN2
SCHEMBL611648 0.84 SRD5A2 (0.70) SRD5A2MAPTRAB9AMAPK1SMN1; SMN2
SCHEMBL7871642 0.84 SRD5A2 (0.70) SRD5A2MAPTRAB9AMAPK1SMN1; SMN2
SCHEMBL4346543 0.84 SRD5A2 (0.70) SRD5A2MAPTRAB9ASMN1; SMN2TSHR
SCHEMBL6654858 0.84 SRD5A2 (0.70) SRD5A2MAPTRAB9AMAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0140050-B1 HEAT SENSITIVE RECORD MATERIAL HODOGAYA CHEMICAL CO., LTD. (JP) 1987-02-04 EP claimed
US-4550329-A CONTAINING HYDROXY SUBSTITUTED BENZOPHENONE HODOGAYA CHEMICAL CO., LTD. (JP) 1985-10-29 US claimed
EP-0140050-A1 Heat sensitive record material HODOGAYA CHEMICAL CO., LTD. (JP) 1985-05-08 EP claimed
EP-2206547-B1 NITROGEN-CONTAINING AROMATIC COMPOUNDS AND PROCESSES FOR THE PRODUCTION OF THE SAME, POLYMERS AND PROTON CONDUCTIVE MEMBRANES OF THESE COMPOUNDS JSR CORP (JP) 2016-03-16 EP disclosed
EP-1906473-B1 ELECTRODE PASTE FOR USE IN SOLID POLYMER FUEL CELL JSR CORP (JP) 2014-02-12 EP disclosed
US-8399148-B2 Varnish for a solid polymer fuel cell JSR CORPORATION (JP) 2013-03-19 US disclosed
EP-1947717-B1 ELECTRODE CATALYST LAYER JSR CORP (JP) 2013-02-13 EP disclosed
US-8273499-B2 Membrane-electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. (JP) 2012-09-25 US disclosed
US-8236206-B2 Electrode catalyst layer JSR CORPORATION (JP) 2012-08-07 US disclosed
US-20120040271-A1 ELECTRODE ELECTROLYTE FOR SOLID POLYMER-TYPE FUEL CELL HONDA MOTOR CO., LTD. (JP) 2012-02-16 US disclosed
US-8043762-B2 Polyphenylene-containing electrode paste JSR CORPORATION (JP) 2011-10-25 US disclosed
US-20060280982-A1 Membrane-electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. 2006-12-14 US disclosed
US-5712226-A Optically active D-pyridyloxy phenoxy propionate herbicides HOECHST AKTIENGESELLSCHAFT (DE) 1998-01-27 US disclosed
EP-0410359-B1 Substituted aminoalkoxy-benzene-derivatives HOFFMANN LA ROCHE (CH) 1994-01-26 EP disclosed
US-5214046-A Synergistic mixtures, inhibitors of sterol biosynthesis HOFFMANN-LA ROCHE INC. (US) 1993-05-25 US disclosed
US-5106878-A Synergistic effects with other fungicides HOFFMANN-LA ROCHE INC. (US) 1992-04-21 US disclosed
EP-0410359-A1 Substituted aminoalkoxy-benzene-derivatives F. HOFFMANN-LA ROCHE AG (CH) 1991-01-30 EP disclosed
EP-0140050-B1 HEAT SENSITIVE RECORD MATERIAL HODOGAYA CHEMICAL CO., LTD. (JP) 1987-02-04 EP disclosed
US-4550329-A CONTAINING HYDROXY SUBSTITUTED BENZOPHENONE HODOGAYA CHEMICAL CO., LTD. (JP) 1985-10-29 US disclosed
EP-0140050-A1 Heat sensitive record material HODOGAYA CHEMICAL CO., LTD. (JP) 1985-05-08 EP disclosed