SCHEMBL6654858

SCHEMBL6654858

Nc1ccc(C(=O)c2ccc(Cl)cc2Cl)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 2/20 0.70
RAB9A P51151 4/20 0.64
MAPT P10636 3/20 0.64
HTT P42858 1/20 0.55
SMN1; SMN2 Q16637 3/20 0.53
TSHR P16473 1/20 0.53
CASP1 P29466 1/20 0.53
KDM4E B2RXH2 2/20 0.51
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
POLB P06746 1/20 0.50
CYP2C9 P11712 1/20 0.50
CHEK2 O96017 1/20 0.49
NPC1 O15118 2/20 0.49
HPGD P15428 1/20 0.49
CASP3 P42574 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
ALDH1A1 P00352 3/20 0.49
MAPK1 P28482 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1149168 0.89 SRD5A2 (0.60) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL7183309 0.89 SRD5A2 (0.54) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL9496067 0.89 SRD5A2 (0.79) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL8437570 0.84 SRD5A2 (0.96) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL610783 0.84 SRD5A2 (0.72) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL8684116 0.84 SRD5A2 (0.72) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL4346543 0.82 SRD5A2 (0.70) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL7871642 0.82 SRD5A2 (0.70) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL12653273 0.82 RECQL (0.60) SRD5A2RAB9AMAPTHTTSMN1; SMN2
SCHEMBL611648 0.82 SRD5A2 (0.70) SRD5A2RAB9AMAPTHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0966424-B1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMA AS (DK) 2004-06-23 EP disclosed
US-6313174-B1 FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) 2001-11-06 US disclosed
EP-0966424-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1999-12-29 EP disclosed
WO-1998032730-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1998-07-30 WO disclosed
US-4313872-A MONDAZO AND DISAZO DYES CASSELLA AKTIENGESELLSCHAFT (DE) 1982-02-02 US disclosed