Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6111468 | 0.88 | MAPK8 (0.38) | KMT2AMAPK1ALDH1A1LMNATSHR | |
| SCHEMBL6109839 | 0.83 | AAK1 (0.32) | ALDH1A1MAPTKDM4ENPSR1HSD17B10 | |
| SCHEMBL6109923 | 0.83 | THRA (0.32) | ALDH1A1KDM4ENPSR1POLBSMN1; SMN2 | |
| SCHEMBL6106931 | 0.82 | RXFP1 (0.33) | KMT2AALDH1A1MAPTNPSR1POLB | |
| SCHEMBL6108262 | 0.82 | ALDH1A1 (0.38) | KMT2APKMALDH1A1CYP1A2KDM4E | |
| SCHEMBL6107056 | 0.81 | THRA (0.33) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL5235937 | 0.81 | MAPT (0.42) | KMT2AMAPK1USP2PKMALOX15 | |
| SCHEMBL6110442 | 0.81 | THRA (0.33) | CYP1A2KDM4EHPGDCYP2C9CYP2C19 | |
| SCHEMBL6109701 | 0.80 | ITGB1 (0.34) | ALDH1A1TSHRKDM4EHPGDHSD17B10 | |
| SCHEMBL5238814 | 0.80 | USP2 (0.42) | KMT2AMAPK1USP2PKMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034039-B2 | Fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-25 | — | — | US | disclosed |