Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFPT1 | Q06210 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 4/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CPS1 | P31327 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766196 | 0.92 | PDE10A (0.39) | GFPT1CSF1RPDE10AEGFRDPP4 | |
| SCHEMBL6108636 | 0.87 | GFPT1 (0.45) | GFPT1PDGFRBCSF1RPDE10AEGFR | |
| Trifluoroacetic Acid SCHEMBL5744985 | 0.87 | GFPT1 (0.47) | GFPT1PDGFRBCSF1RPDE10AEGFR | |
| SCHEMBL5745267 | 0.86 | GFPT1 (0.46) | GFPT1PDGFRBCSF1RPDE10AEGFR | |
| SCHEMBL6110313 | 0.85 | GFPT1 (0.51) | GFPT1PDGFRBCSF1RPDE10AMAPK7 | |
| SCHEMBL5768599 | 0.85 | GFPT1 (0.61) | GFPT1PDGFRBPDE10AMAPK7APAF1 | |
| Trifluoroacetic Acid SCHEMBL5743418 | 0.81 | GFPT1 (0.46) | GFPT1PDGFRBCSF1RPDE10AEGFR | |
| SCHEMBL5746074 | 0.81 | GFPT1 (0.45) | GFPT1PDGFRBCSF1RPDE10AEGFR | |
| SCHEMBL6111064 | 0.80 | CSF1R (0.40) | GFPT1CSF1RPDE10ADPP4KDR | |
| Trifluoroacetic Acid SCHEMBL5744981 | 0.80 | GFPT1 (0.53) | GFPT1PDGFRBPDE10AEGFRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067529-B2 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-20040259910-A1 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | BOLIN DAVID ROBERT (US) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259910-A1 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | GFPT1, GLS2, GLS | GFPT1 1/4885PDGFRB 1671/4885CSF1R 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.