Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | RORA | P35398 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | OXER1 | Q8TDS5 | 3/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6109066 | 0.85 | DPP4 (0.40) | DPP4RORARORCNR1H2RORB | |
| SCHEMBL6108264 | 0.83 | ALDH1A1 (0.38) | KDM4EGAAHPGDMEN1POLB | |
| SCHEMBL5233023 | 0.82 | DPP4 (0.49) | DPP4RORARORCNR1H2RORB | |
| SCHEMBL6106935 | 0.81 | PTGER4 (0.32) | GAAPOLB | |
| SCHEMBL6108888 | 0.81 | RORA (0.36) | DPP4RORARORCRORBKDM4E | |
| SCHEMBL6107104 | 0.81 | RORA (0.36) | DPP4RORARORCRORBGAA | |
| SCHEMBL6109924 | 0.81 | DPP4 (0.32) | DPP4GAAPOLB | |
| SCHEMBL5237189 | 0.81 | DPP4 (0.50) | DPP4RORARORCNR1H2RORB | |
| SCHEMBL5240942 | 0.81 | DPP4 (0.47) | DPP4RORARORCNR1H2RORB | |
| SCHEMBL6109932 | 0.80 | KDM4E (0.34) | DPP4RORARORCRORBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034039-B2 | Fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-25 | — | — | US | disclosed |