Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.71 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.42 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731229 | 0.90 | SIGMAR1 (0.69) | SIGMAR1LOXL2TAAR1SLC18A2SLC6A2 | |
| SCHEMBL10242800 | 0.85 | SIGMAR1 (0.71) | SIGMAR1TAAR1SLC18A2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL2140145 | 0.84 | SIGMAR1 (0.69) | SIGMAR1TAAR1SLC18A2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL2140139 | 0.84 | SIGMAR1 (0.69) | SIGMAR1TAAR1SLC18A2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL12096441 | 0.84 | SIGMAR1 (0.69) | SIGMAR1TAAR1SLC18A2SLC6A2SLC6A4 | |
| SCHEMBL9322567 | 0.84 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2SLC6A2SLC6A4 | |
| SCHEMBL3628122 | 0.81 | SIGMAR1 (0.65) | SIGMAR1ADRB2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3625561 | 0.80 | SIGMAR1 (0.63) | SIGMAR1ADRB2SLC2A1BCHENPC1 | |
| Hydrochloric Acid SCHEMBL732028 | 0.80 | SIGMAR1 (0.63) | SIGMAR1ADRB2SLC2A1BCHENPC1 | |
| Hydrochloric Acid SCHEMBL3915133 | 0.80 | SIGMAR1 (0.63) | SIGMAR1SLC2A1BCHENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006051373-A1 | COMPOUNDS FOR THE TREATMENT OF DISEASES | PFIZER LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |