Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.71 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12096441 | 0.98 | SIGMAR1 (0.69) | SIGMAR1SLC2A1TAAR1SLC18A2ADRB2 | |
| Hydrochloric Acid SCHEMBL2140139 | 0.98 | SIGMAR1 (0.69) | SIGMAR1SLC2A1TAAR1SLC18A2ADRB2 | |
| Hydrochloric Acid SCHEMBL2140145 | 0.98 | SIGMAR1 (0.69) | SIGMAR1SLC2A1TAAR1SLC18A2ADRB2 | |
| SCHEMBL6110554 | 0.85 | SIGMAR1 (0.71) | SIGMAR1SLC2A1TAAR1SLC18A2ADRB2 | |
| SCHEMBL3628122 | 0.84 | SIGMAR1 (0.65) | SIGMAR1ADRB2NPC1RAB9ALMNA | |
| SCHEMBL731229 | 0.84 | SIGMAR1 (0.69) | SIGMAR1SLC2A1TAAR1SLC18A2ADRB2 | |
| SCHEMBL9322567 | 0.84 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2ADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL3915133 | 0.83 | SIGMAR1 (0.63) | SIGMAR1SLC2A1NPC1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL732028 | 0.83 | SIGMAR1 (0.63) | SIGMAR1SLC2A1ADRB2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3625561 | 0.83 | SIGMAR1 (0.63) | SIGMAR1SLC2A1ADRB2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629271-B2 | Compounds | ASTRAZENECA AB (GB) | 2014-01-14 | — | — | US | disclosed |
| US-8629271-B2 | Compounds | ASTRAZENECA AB (GB) | 2014-01-14 | — | — | US | disclosed |
| US-20120322788-A1 | Compouds | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2012-12-20 | — | — | US | disclosed |
| US-20120322788-A1 | Compouds | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2012-12-20 | — | — | US | disclosed |
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| WO-2009098448-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322788-A1 | Compouds | PKD1, SBDS, ABCB11 | SIGMAR1 426/4885SLC2A1 1240/4885TAAR1 2334/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | SIGMAR1 765/4885SLC2A1 1059/4885TAAR1 1986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.