Sugi Predict

Sugi Predict / Compounds / SCHEMBL6111172

SCHEMBL6111172

SCHEMBL6111172

C#Cc1cccc(NC(=O)Cc2ccc(O)c(OC)c2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 5/20 0.57
▸ HTT P42858 4/20 0.57
▸ KMT2A Q03164 3/20 0.57
▸ LMNA P02545 3/20 0.57
▸ STAT3 P40763 1/20 0.55
▸ NLRP3 Q96P20 1/20 0.51
▸ HDAC3 O15379 2/20 0.51
▸ EGFR P00533 2/20 0.51
▸ HDAC4 P56524 2/20 0.51
▸ HDAC1 Q13547 2/20 0.51
▸ HDAC7 Q8WUI4 2/20 0.51
▸ HDAC2 Q92769 2/20 0.51
▸ HDAC10 Q969S8 2/20 0.51
▸ HDAC11 Q96DB2 2/20 0.51
▸ HDAC8 Q9BY41 2/20 0.51
▸ HDAC6 Q9UBN7 2/20 0.51
▸ HDAC9 Q9UKV0 2/20 0.51
▸ HDAC5 Q9UQL6 2/20 0.51
▸ ALDH1A1 P00352 2/20 0.50
▸ TSHR P16473 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6098671 0.89 SMN1; SMN2 (0.57) SMN1; SMN2HTTKMT2ALMNASTAT3
SCHEMBL6098990 0.82 SMN1; SMN2 (0.60) SMN1; SMN2HTTKMT2ALMNASTAT3
SCHEMBL6100015 0.82 HTT (0.50) SMN1; SMN2HTTKMT2ALMNASTAT3
SCHEMBL6101644 0.81 SMN1; SMN2 (0.64) SMN1; SMN2HTTKMT2ALMNASTAT3
SCHEMBL6100978 0.81 KDM4E (0.65) SMN1; SMN2HTTKMT2ALMNASTAT3
SCHEMBL14041458 0.81 LMNA (0.63) SMN1; SMN2HTTKMT2ALMNANLRP3
SCHEMBL6099398 0.81 KMT2A (0.64) SMN1; SMN2HTTKMT2ALMNASTAT3
SCHEMBL25769880 0.81 NLRP3 (0.61) SMN1; SMN2HTTKMT2ALMNASTAT3
SCHEMBL29079361 0.80 LMNA (0.59) KMT2ALMNANLRP3HDAC3EGFR
SCHEMBL30624459 0.80 LMNA (0.59) KMT2ALMNANLRP3HDAC3EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1282640-C N-arylphenylacetamide derivatives and medicinal compositions containing same DAINIPPON PHARMACEUTICAL CO (JP) 2006-11-01 — — CN disclosed
US-7084176-B2 N-arylphenylacetamide derivatives and medicinal compositions containing the same DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2006-08-01 — — US disclosed
US-20040248983-A1 N-arylphenylacetamide derivatives and medicinal compositions containing the same DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2004-12-09 — — US disclosed
CN-1529692-A N-arylphenylacetamide derivatives and medicinal compositions containing same 大日本制药株式会社 2004-09-15 — — CN disclosed
EP-1403235-A1 N-ARYLPHENYLACETAMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME Dainippon Pharmaceutical Co., Ltd. (JP) 2004-03-31 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248983-A1 N-arylphenylacetamide derivatives and medicinal compositions containing the same HRH2, CCR8, CYP2C8 SMN1; SMN2 2474/4885HTT 1276/4885KMT2A 1631/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.