Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 14/20 | 0.47 |
| ▸ | DRD2 | P14416 | 12/20 | 0.47 |
| ▸ | DRD4 | P21917 | 9/20 | 0.47 |
| ▸ | DRD1 | P21728 | 4/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110698 | 0.90 | NCF1 (0.43) | DRD3DRD2DRD4NCF1PRMT5 | |
| SCHEMBL6111842 | 0.86 | DRD2 (0.61) | DRD3DRD2DRD4GRM5HRH3 | |
| SCHEMBL6111524 | 0.83 | DRD2 (0.64) | DRD3DRD2DRD4HRH3 | |
| SCHEMBL6111107 | 0.83 | GRM5 (0.46) | DRD3DRD2DRD4DRD1GRM5 | |
| SCHEMBL6111949 | 0.81 | NCF1 (0.45) | DRD3DRD2DRD4NCF1 | |
| SCHEMBL6110539 | 0.80 | DRD2 (0.52) | DRD3DRD2DRD4HRH3 | |
| SCHEMBL582220 | 0.79 | GRM5 (0.51) | GRM5PRMT5WDR77HRH3 | |
| SCHEMBL6111756 | 0.79 | KCNH2 (0.46) | DRD3DRD2DRD4GRM5PRMT5 | |
| SCHEMBL6111322 | 0.76 | DRD2 (0.50) | DRD3DRD2DRD4GRM5NCF1 | |
| SCHEMBL1817669 | 0.76 | GRM5 (0.61) | GRM5PRMT5WDR77HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006048727-A1 | PIPERAZINYLPHENALKYL LACTAM/AMINE LIGANDS FOR THE 5HT1B RECEPTOR | PFIZER PRODUCTS INC. (US) | 2006-05-11 | — | — | WO | claimed |