Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30001425 | 0.89 | ALDH1A1 (0.43) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL320440 | 0.89 | ALDH1A1 (0.43) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL320439 | 0.89 | ALDH1A1 (0.43) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL6118689 | 0.89 | ALDH1A1 (0.43) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL21798639 | 0.87 | ALDH1A1 (0.42) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL1148936 | 0.82 | GAA (0.41) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL2337309 | 0.82 | GAA (0.41) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL17404667 | 0.80 | GAA (0.45) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL5245093 | 0.80 | GBA1 (0.46) | GAAGBA1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL5830519 | 0.80 | GBA1 (0.46) | GAAGBA1ALDH1A1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130324530-A1 | 3-(AMINOARYL)-PYRIDINE COMPOUNDS | NOVARTIS AG | 2013-12-05 | — | — | US | disclosed |
| EP-2668162-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | Novartis AG (CH) | 2013-12-04 | — | — | EP | disclosed |
| US-20130303507-A1 | SUBSTITUTED HETERO-BIARYL COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2013-11-14 | — | — | US | disclosed |
| US-20130303507-A1 | SUBSTITUTED HETERO-BIARYL COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2013-11-14 | — | — | US | disclosed |
| EP-2640702-A1 | 3-(AMINOARYL)-PYRIDINE COMPOUNDS | Novartis AG (CH) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012101065-A2 | PYRIMIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101066-A1 | PYRIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101062-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012066065-A1 | PHENYL-HETEROARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-05-24 | — | — | WO | disclosed |
| WO-2012066070-A1 | 3-(AMINOARYL)-PYRIDINE COMPOUNDS | NOVARTIS AG (CH) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130324530-A1 | 3-(AMINOARYL)-PYRIDINE COMPOUNDS | CDK9, CDK19, CDK3 | GAA 1354/4885GBA1 3131/4885ALDH1A1 1949/4885 |
| US-20130303507-A1 | SUBSTITUTED HETERO-BIARYL COMPOUNDS AND THEIR USES | CDK9, CDK19, CDK3 | GAA 2215/4885GBA1 1878/4885ALDH1A1 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.