Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 10/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 10/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.51 |
| ▸ | CDK2 | P24941 | 8/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611780 | 0.80 | CDC7 (0.61) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL611907 | 0.75 | CDC7 (0.67) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL614152 | 0.74 | CDC7 (0.72) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL614124 | 0.73 | CDC7 (0.66) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL614240 | 0.73 | CDC7 (0.53) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL612281 | 0.68 | CDC7 (1.00) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL613553 | 0.62 | CDC7 (0.70) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL614653 | 0.61 | CDC7 (0.57) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL613725 | 0.60 | CDC7 (0.71) | CDC7DBF4CCNE1CDK2ROCK1 | |
| SCHEMBL11725186 | 0.60 | ALDH1A1 (0.40) | CDC7DBF4CCNE1CDK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8691828-B2 | Thienopyrimidine as CDC7 kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-08 | — | — | US | disclosed |
| US-8691828-B2 | Thienopyrimidine as CDC7 kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-08 | — | — | US | disclosed |
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-16 | — | — | US | disclosed |
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-16 | — | — | US | disclosed |
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | CDC7, CDK7, DTYMK | CDC7 1/4885DBF4 593/4885CCNE1 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.