Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
| ▸ | CFTR | P13569 | 6/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22866081 | 0.83 | CFTR (0.52) | NOTUMCFTRSOS1MAPTGAA | |
| SCHEMBL31016073 | 0.83 | CFTR (0.52) | NOTUMCFTRSOS1MAPTGAA | |
| SCHEMBL6119419 | 0.82 | XDH (0.45) | LMNAMAPTXDHCYP46A1GAA | |
| SCHEMBL5509482 | 0.81 | XDH (0.40) | NOTUMCFTRSOS1MAPTXDH | |
| SCHEMBL6119213 | 0.81 | CFTR (0.54) | NOTUMCFTRSOS1MAPTGAA | |
| SCHEMBL6120235 | 0.80 | NOTUM (0.46) | NOTUMCFTRSOS1LMNASMN1; SMN2 | |
| SCHEMBL6119252 | 0.80 | SOS1 (0.42) | SOS1LMNAMAPTXDHCYP46A1 | |
| SCHEMBL6119249 | 0.78 | SOS1 (0.40) | NOTUMCFTRSOS1MAPTXDH | |
| SCHEMBL22866327 | 0.78 | NOTUM (0.43) | NOTUMCFTRSOS1HTTLMNA | |
| SCHEMBL30689784 | 0.78 | NOTUM (0.43) | NOTUMCFTRSOS1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067663-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |