Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 2/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991900 | 0.92 | BRAF (0.39) | BRAFWDR5 | |
| SCHEMBL6120724 | 0.87 | KDM4E (0.38) | KDM4EALDH1A1MAPTMAPK1WDR5 | |
| SCHEMBL6120612 | 0.85 | MAPT (0.38) | ALDH1A1MAPTMALT1 | |
| SCHEMBL6121078 | 0.84 | PTGES2 (0.35) | BRAFWDR5 | |
| SCHEMBL6120639 | 0.83 | WDR5 (0.37) | BRAFWDR5 | |
| SCHEMBL6120874 | 0.83 | BRAF (0.36) | BRAFWDR5 | |
| SCHEMBL2989868 | 0.83 | BRAF (0.45) | BRAF | |
| SCHEMBL2994080 | 0.82 | BRAF (0.38) | BRAFWDR5 | |
| SCHEMBL6121119 | 0.81 | BRAF (0.36) | BRAFWDR5 | |
| SCHEMBL2999832 | 0.80 | BRAF (0.46) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067664-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |