Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9285883 | 0.83 | TDP1 (0.64) | TDP1TSHRMAPTLMNAALDH1A1 | |
| Fluoride SCHEMBL28506026 | 0.82 | MAPT (0.62) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL28621447 | 0.82 | TDP1 (0.62) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL3973537 | 0.78 | MAPT (0.69) | TDP1TSHRMAPK1MAPTLMNA | |
| SCHEMBL29378383 | 0.78 | TDP1 (1.00) | TDP1TSHRMAPK1MAPTLMNA | |
| SCHEMBL121896 | 0.78 | TDP1 (1.00) | TDP1TSHRMAPK1MAPTLMNA | |
| SCHEMBL7058241 | 0.77 | MAPT (0.47) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL31553358 | 0.77 | TDP1 (0.73) | TDP1TSHRMAPK1MAPTALDH1A1 | |
| SCHEMBL2867570 | 0.77 | TDP1 (0.73) | TDP1TSHRMAPK1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL28403392 | 0.77 | TDP1 (0.96) | TDP1TSHRMAPK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299259-B | Preparation method of 2-amino-5-thiophenyl- (2-methoxy) acetanilide | 珠海优润医药科技有限公司 | 2020-08-07 | — | — | CN | claimed |
| CN-108299259-A | The preparation method of 2- amino -5- thiophenyls-(2- methoxyl groups) antifebrin | 珠海优润医药科技有限公司 | 2018-07-20 | — | — | CN | claimed |
| CN-116496192-B | Preparation method of 4-phenylthio-1, 2-phenylenediamine | 山东国邦药业有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-116496192-A | Preparation method of 4-phenylthio-1, 2-phenylenediamine | 山东国邦药业有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-114716354-B | Synthesis method of fenbendazole intermediate 2-nitro-4-thiophenylaniline | 山东国邦药业有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-114716354-A | Synthesis method of fenbendazole intermediate 2-nitro-4-thiophenyl aniline | 山东国邦药业有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-108299259-B | Preparation method of 2-amino-5-thiophenyl- (2-methoxy) acetanilide | 珠海优润医药科技有限公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-108299259-B | Preparation method of 2-amino-5-thiophenyl- (2-methoxy) acetanilide | 珠海优润医药科技有限公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-108299259-A | The preparation method of 2- amino -5- thiophenyls-(2- methoxyl groups) antifebrin | 珠海优润医药科技有限公司 | 2018-07-20 | — | — | CN | disclosed |
| US-9321777-B2 | 6-triazolopyridazine sulfanyl benzothiazole derivatives as MET inhibitors | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| US-9321777-B2 | 6-triazolopyridazine sulfanyl benzothiazole derivatives as MET inhibitors | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| EP-2178881-A2 | NOVEL 6-TRIAZOLOPYRIDAZINESULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS AND NOVEL USE AS MET INHIBITORS | Sanofi-Aventis (FR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009056692-A2 | NOVEL 6-TRIAZOLOPYRIDAZINESULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS AND NOVEL USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009056692-A2 | NOVEL 6-TRIAZOLOPYRIDAZINESULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS AND NOVEL USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | WO | disclosed |
| US-4156006-A | ANTHELMINTICS | E. R. SQUIBB & SONS, INC. (US) | 1979-05-22 | — | — | US | disclosed |
| US-4080461-A | PESTICIDES, FUNGICIDES | SYNTEX (U.S.A.) INC. (US) | 1978-03-21 | — | — | US | disclosed |
| US-4072696-A | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity | SYNTEX (U.S.A.) INC. (US) | 1978-02-07 | — | — | US | disclosed |
| US-4005202-A | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity | SYNTEX (U.S.A.) INC. (US) | 1977-01-25 | — | — | US | disclosed |
| US-4002640-A | ANTIFUNGAL AGENTS | SYNTEX (U.S.A.) INC. (US) | 1977-01-11 | — | — | US | disclosed |
| US-3935209-A | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity | SYNTEX (U.S.A.) INC. (US) | 1976-01-27 | — | — | US | disclosed |