Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16303628 | 0.72 | KDR (0.64) | JAK1MAPTMEN1KMT2ATSHR | |
| SCHEMBL22494221 | 0.70 | RAB9A (0.62) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL24185627 | 0.69 | NPC1 (0.47) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL15698733 | 0.69 | CDK8 (0.66) | EGLN2JAK1MEN1KMT2AALDH1A1 | |
| SCHEMBL11377976 | 0.68 | SMN1; SMN2 (0.47) | EGLN2MEN1KMT2AMAPK14JAK2 | |
| SCHEMBL13579637 | 0.68 | KDR (0.49) | JAK1MAPTLMNAMEN1KMT2A | |
| SCHEMBL6118992 | 0.68 | SCN5A (0.64) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL6118164 | 0.67 | SCN5A (0.58) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL3090231 | 0.67 | JAK1 (1.00) | EGLN2JAK1MEN1KMT2AALDH1A1 | |
| SCHEMBL1422714 | 0.67 | JAK1 (0.70) | EGLN2JAK1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065297-A1 | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2012-05-24 | — | — | WO | claimed |
| WO-2012065297-A1 | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2012-05-24 | — | — | WO | disclosed |