Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6126206 | 0.93 | MAOB (0.41) | NPC1MAPTRAB9APOLBMAPK1 | |
| SCHEMBL1663835 | 0.86 | MAPK10 (0.40) | NPC1MAPTRAB9AMAPK10MAPK8 | |
| SCHEMBL1665219 | 0.86 | MAPK10 (0.43) | NPC1MAPTRAB9APOLBMAPK10 | |
| SCHEMBL1665046 | 0.85 | TNIK (0.44) | NPC1MAPTRAB9APOLBMAPK10 | |
| SCHEMBL6126290 | 0.85 | CHRNA7 (0.51) | NPC1MAPTRAB9AMAPK1MAPK10 | |
| SCHEMBL1664777 | 0.85 | MAPK10 (0.41) | NPC1MAPTRAB9AMAPK10MAPK8 | |
| SCHEMBL1664303 | 0.82 | MAPK10 (0.45) | NPC1MAPTRAB9AMAPK10MAPK8 | |
| SCHEMBL1665212 | 0.82 | NPC1 (0.53) | NPC1RAB9AMAPK10MAPK8MAPK13 | |
| SCHEMBL1665075 | 0.82 | NPC1 (0.41) | NPC1MAPTRAB9AMAPK1MAPK10 | |
| SCHEMBL1665076 | 0.81 | NPC1 (0.49) | NPC1MAPTRAB9ATNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |