Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.33 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858433 | 0.90 | PIK3CA (0.40) | PIK3CAPRKDCTNIKPIK3CDPIK3CB | |
| SCHEMBL3806243 | 0.81 | PIK3CA (0.44) | PIK3CAPRKDCTNIKPIK3CDPIK3CB | |
| SCHEMBL859543 | 0.80 | GPR84 (0.33) | PIK3CAPRKDCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3765105 | 0.80 | GPR142 (0.33) | PIK3CAPRKDCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL861137 | 0.80 | PIK3CD (0.36) | PIK3CAPRKDCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL855869 | 0.79 | PIK3CD (0.35) | TNIKPIK3CDPIK3CBGPR142 | |
| SCHEMBL857772 | 0.78 | PIK3CD (0.33) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL856960 | 0.78 | GPR142 (0.35) | PIK3CATNIKPIK3CDPIK3CBPIK3CG | |
| SCHEMBL857756 | 0.77 | AOC3 (0.35) | PIK3CAGPR142 | |
| SCHEMBL856810 | 0.77 | PIK3CD (0.32) | PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |