Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 14/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.49 |
| ▸ | GCGR | P47871 | 13/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | FRK | P42685 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198096 | 0.82 | MAPK11 (0.65) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL6605606 | 0.82 | MAPK11 (0.65) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL29406707 | 0.79 | TGFBR1 (0.64) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL9192799 | 0.78 | MAPK11 (0.75) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| Sb-203580 SCHEMBL146399 | 0.78 | MAPK11 (0.75) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| Sb-203580 SCHEMBL25800837 | 0.78 | MAPK11 (0.75) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| Sb-203580 SCHEMBL95208 | 0.78 | MAPK11 (0.75) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| Sb-203580 SCHEMBL220990 | 0.78 | MAPK11 (0.75) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| Sb-203580 SCHEMBL27075368 | 0.78 | MAPK11 (0.75) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| Sb-203580 SCHEMBL4890447 | 0.77 | MAPK11 (0.73) | MAPK14MAPK11MAPK13GCGRMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043212-A1 | Differential inhibition of p38 map kinase isoforms | SCIOS, INC. | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043212-A1 | Differential inhibition of p38 map kinase isoforms | MAP2K2, MAP2K5, MAP2K7 | MAPK14 35/4885MAPK11 43/4885MAPK13 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.