Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | POLA1 | P09884 | 1/20 | 0.52 |
| ▸ | POLD1 | P28340 | 1/20 | 0.52 |
| ▸ | TYMS | P04818 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129081 | 1.00 | POLB (0.52) | POLBPOLA1POLD1TYMS | |
| SCHEMBL6130170 | 0.94 | POLB (0.54) | POLBPOLA1POLD1TYMS | |
| SCHEMBL8059303 | 0.86 | TYMS (0.64) | TYMS | |
| SCHEMBL23701491 | 0.84 | P2RY6 (0.59) | POLBPOLA1POLD1TYMS | |
| SCHEMBL18152601 | 0.83 | POLB (0.56) | POLBPOLA1POLD1TYMS | |
| SCHEMBL22322707 | 0.80 | TYMS (0.65) | POLBPOLA1POLD1TYMS | |
| SCHEMBL7752314 | 0.80 | TYMS (0.50) | POLBTYMS | |
| SCHEMBL1763106 | 0.80 | POLB (0.62) | POLBPOLA1POLD1TYMS | |
| SCHEMBL26779534 | 0.80 | POLB (0.62) | POLBPOLA1POLD1TYMS | |
| SCHEMBL8371071 | 0.80 | POLB (0.62) | POLBPOLA1POLD1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050164182-A1 | Nucleoside comprising reporter molecule cleavable by hydrolase such as esterases, phosphatases, peptidases, penicillin amidases, glycosidases, and phosphorylases; limits polymerase activity; sequencing; solid phase synthesis | GE HEALTHCARE UK LIMITED (GB) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050164182-A1 | Nucleoside comprising reporter molecule cleavable by hydrolase such as esterases, phosphatases, peptidases, penicillin amidases, glycosidases, and phosphorylases; limits polymerase activity; sequencing; solid phase synthesis | PNP, PEPD, DNPEP | POLB 402/4885POLA1 205/4885POLD1 441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.