Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TYMS | P04818 | 7/20 | 0.54 |
| ▸ | POLA1 | P09884 | 1/20 | 0.53 |
| ▸ | POLD1 | P28340 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129081 | 0.94 | POLB (0.52) | POLBTYMSPOLA1POLD1 | |
| SCHEMBL6129083 | 0.94 | POLB (0.52) | POLBTYMSPOLA1POLD1 | |
| SCHEMBL8059303 | 0.91 | TYMS (0.64) | TYMS | |
| SCHEMBL18152601 | 0.86 | POLB (0.56) | POLBTYMSPOLA1POLD1 | |
| SCHEMBL22322707 | 0.85 | TYMS (0.65) | POLBTYMSPOLA1POLD1 | |
| SCHEMBL7752314 | 0.85 | TYMS (0.50) | POLBTYMS | |
| Lithium Ion SCHEMBL8844072 | 0.84 | TYMS (0.49) | POLBTYMS | |
| Biotin SCHEMBL9328971 | 0.83 | F2 (0.46) | POLBTYMSPOLA1POLD1 | |
| SCHEMBL6462543 | 0.83 | POLB (0.62) | POLBTYMSPOLA1POLD1 | |
| SCHEMBL149769 | 0.83 | POLB (0.62) | POLBTYMSPOLA1POLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6054442-A | THE INCORPORATION OF NUCLEOTIDE ANALOGS, SUCH AS 7-DEAZA-2'-DEOXYQUANOSINE-5'-TRIPHOSPHATE AFFECTED THE PROCESSIVITY OF TELOMERASE, CONVERTING PROCESSIVE TELOMERASE TO NON-PROCESSIVE TELOMERASE. | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM | 2000-04-25 | — | — | US | claimed |
| EP-1326523-A4 | IMAGING OF ENZYMATIC ACTIVITY | GEN HOSPITAL CORP (US) | 2005-01-05 | — | — | EP | disclosed |
| US-20040241096-A1 | Detect enzyme activity in sample; incubation target tissue; detect amplification in sample | THE GENERAL HOSPITAL CORPORATION, A MASSACHUSETTS CORPORATION | 2004-12-02 | — | — | US | disclosed |
| US-6737247-B2 | DETECTING ENZYMATIC ACTIVITY IN SAMPLE; OBTAIN SUBSTRATE, INCUBATE WITH TARGET TISSUE, DETECT AMPLIFIED RELAXIVITY OF SAMPLE, EVALUATE ENZYMATIC ACTIVITY SAMPLE | THE GENERAL HOSPITAL CORPORATION | 2004-05-18 | — | — | US | disclosed |
| EP-1326523-A2 | IMAGING OF ENZYMATIC ACTIVITY | THE GENERAL HOSPITAL CORPORATION (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6593306-B1 | Prematurely shortening a telomere in a cell comprising administering to said cell in an animal in an amount of 7-deaza nucleoside in an amount sufficient to inhibit telomere extension, reduced proliferative capacity leads to cell death | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMS | 2003-07-15 | — | — | US | disclosed |
| WO-2002032291-A9 | IMAGING OF ENZYMATIC ACTIVITY | GEN HOSPITAL CORP (US) | 2003-04-17 | — | — | WO | disclosed |
| US-20020127629-A1 | Imaging of enzymatic activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-09-12 | — | — | US | disclosed |
| WO-2002032291-A2 | IMAGING OF ENZYMATIC ACTIVITY | THE GENERAL HOSPITAL CORPORATION (US) | 2002-04-25 | — | — | WO | disclosed |
| EP-0798387-B1 | Method of detecting nucleic acid | TOYODA CHUO KENKYUSHO KK (JP) | 2001-01-24 | — | — | EP | disclosed |
| US-6004939-A | INHIBITING CELL GROWTH WITH 7-DEAZA-2*-DEOXYNUCLEOSIDE; ANTICARCINOGENIC AGENTS | CTRC RESEARCH FOUNDATION BOARD OF REGENTS (US) | 1999-12-21 | — | — | US | disclosed |
| US-5728531-A | HYBRIDIZING DNA PROBE LABELED WITH A GIBBERELLIN TO A NUCLEIC ACID, BINDING LABELED ANTIBODY TO HYBRID AND DETECTING LABELED ANTIBODY AND THEREBY THE NUCLEIC ACID | KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0798387-A1 | Method of detecting nucleic acid | KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) | 1997-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020127629-A1 | Imaging of enzymatic activity | MMP1, ENGASE, MMP2 | POLB 1682/4885TYMS 2319/4885POLA1 774/4885 |
| US-20040241096-A1 | Detect enzyme activity in sample; incubation target tissue; detect amplification in sample | MMP1, ENGASE, MMP2 | POLB 288/4885TYMS 2409/4885POLA1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.