SCHEMBL6129596

SCHEMBL6129596

CCCCCc1cc(C(=O)C(=O)O)c2c3c(C(N)=O)cccc3n(Cc3ccccc3)c2c1

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARG P37231 7/20 0.45
PLA2G2A P14555 13/20 0.42
PLA2G10 O15496 1/20 0.39
PLA2G1B P04054 1/20 0.39
PLA2G5 P39877 1/20 0.39
PLA2G2E Q9NZK7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5212214 0.89 PPARG (0.46) PPARGPLA2G2A
SCHEMBL7967403 0.88 PPARG (0.36) PPARGPLA2G2APLA2G1B
SCHEMBL8053026 0.87 PLA2G2A (0.42) PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E
SCHEMBL27844981 0.85 PPARG (0.42) PPARGPLA2G2APLA2G10PLA2G1BPLA2G5
SCHEMBL6534808 0.84 PLA2G2A (0.43) PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E
SCHEMBL29862634 0.84 PLA2G2A (0.49) PPARGPLA2G2APLA2G10PLA2G1BPLA2G5
SCHEMBL818833 0.84 PLA2G2A (0.49) PPARGPLA2G2APLA2G10PLA2G1BPLA2G5
SCHEMBL6129597 0.83 PPARG (0.43) PPARGPLA2G2APLA2G10PLA2G1BPLA2G5
SCHEMBL6776320 0.83 PPARG (0.41) PPARGPLA2G2APLA2G10
SCHEMBL6781319 0.83 PPARG (0.42) PPARGPLA2G2APLA2G1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1043991-A4 TREATMENT FOR ALZHEIMER'S DISEASE LILLY CO ELI (US) 2005-02-02 EP claimed
EP-1011670-A4 METHOD FOR TREATMENT OF NON-RHEUMATOID ATHRITIS LILLY CO ELI (US) 2004-10-27 EP claimed
JP-2004503586-A 2004-02-05 JP claimed
EP-1303262-A2 USE OF A SPLA2 INHIBITOR FOR THE TREATMENT OF SEPSIS ELI LILLY AND COMPANY (US) 2003-04-23 EP claimed
EP-1259260-A1 COMBINATION THERAPY FOR THE TREATMENT OF INFLAMMATORY AND RESPIRATORY DISEASES ELI LILLY AND COMPANY (US) 2002-11-27 EP claimed
EP-1214041-A2 COMBINATION THERAPY FOR THE TREATMENT OF SEPSIS ELI LILLY AND COMPANY (US) 2002-06-19 EP claimed
WO-2002005796-A2 USE OF A SPLA2 INHIBITOR FOR THE TREATMENT OF SEPSIS ELI LILLY AND COMPANY (US) 2002-01-24 WO claimed
JP-2001522884-A 2001-11-20 JP claimed
WO-2001049323-A1 COMBINATION THERAPY FOR THE TREATMENT OF INFLAMMATORY AND RESPIRATORY DISEASES ELI LILLY AND COMPANY (US) 2001-07-12 WO claimed
EP-1043991-A1 TREATMENT FOR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 2000-10-18 EP claimed
WO-2000037022-A2 COMBINATION THERAPY FOR THE TREATMENT OF SEPSIS ELI LILLY AND COMPANY (US) 2000-06-29 WO claimed
EP-1011670-A1 METHOD FOR TREATMENT OF NON-RHEUMATOID ATHRITIS ELI LILLY AND COMPANY (US) 2000-06-28 EP claimed
EP-1007056-A1 METHOD FOR THE TREATMENT OF CYSTIC FIBROSIS ELI LILLY AND COMPANY (US) 2000-06-14 EP claimed
WO-1999025340-A1 TREATMENT FOR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1999-05-27 WO claimed
WO-1999016453-A1 METHOD FOR THE TREATMENT OF CYSTIC FIBROSIS ELI LILLY AND COMPANY (US) 1999-04-08 WO claimed
WO-1999009978-A1 METHOD FOR TREATMENT OF NON-RHEUMATOID ATHRITIS ELI LILLY AND COMPANY (US) 1999-03-04 WO claimed
EP-1043991-A4 TREATMENT FOR ALZHEIMER'S DISEASE LILLY CO ELI (US) 2005-02-02 EP disclosed
EP-1011670-A4 METHOD FOR TREATMENT OF NON-RHEUMATOID ATHRITIS LILLY CO ELI (US) 2004-10-27 EP disclosed
WO-1999016453-A1 METHOD FOR THE TREATMENT OF CYSTIC FIBROSIS ELI LILLY AND COMPANY (US) 1999-04-08 WO disclosed
WO-1999009978-A1 METHOD FOR TREATMENT OF NON-RHEUMATOID ATHRITIS ELI LILLY AND COMPANY (US) 1999-03-04 WO disclosed