Phosphonic Acid

Phosphonic Acid

SCHEMBL6130474

O=C1C=CC(=O)C(C(=O)O)=C1.O=[PH](O)O

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 2/20 0.38
HPGD P15428 2/20 0.38
ALOX12 P18054 2/20 0.38
RECQL P46063 2/20 0.38
KMT2A Q03164 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
C9 P02748 2/20 0.38
KDM4E B2RXH2 1/20 0.38
IKBKB O14920 1/20 0.38
RGS12 O14924 1/20 0.38
GMNN O75496 1/20 0.38
USP2 O75604 1/20 0.38
MYC P01106 1/20 0.38
LMNA P02545 1/20 0.38
CYP1A2 P05177 1/20 0.38
POLB P06746 1/20 0.38
CYP2D6 P10635 1/20 0.38
HSPD1 P10809 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL865959 0.91 ALDH1A1 (0.42) MEN1ALDH1A1MAPTHPGDALOX12
SCHEMBL28198484 0.89 ALDH1A1 (0.41) MEN1ALDH1A1MAPTHPGDALOX12
SCHEMBL28736224 0.75 C9 (0.41) MEN1ALDH1A1MAPTHPGDALOX12
SCHEMBL28327160 0.74 TDP1 (0.42) MEN1ALDH1A1MAPTHPGDALOX12
SCHEMBL6130475 0.74 SETD7 (0.33) MEN1ALDH1A1MAPTHPGDALOX12
SCHEMBL26444866 0.73 ALDH1A1 (0.37) MEN1ALDH1A1MAPTHPGDALOX12
SCHEMBL10964095 0.70 ALOX15 (0.36) MEN1ALDH1A1MAPTHPGDALOX12
SCHEMBL1287162 0.70 ERBB2 (0.39) MEN1ALDH1A1MAPTHPGDALOX12
SCHEMBL2257187 0.70 ALDH1A1 (0.44) MEN1ALDH1A1MAPTHPGDALOX12
Water SCHEMBL28540739 0.68 ERBB2 (0.38) MEN1ALDH1A1MAPTHPGDALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1427404-A4 TREATMENT OF GLIAL TUMORS WITH GLUTAMATE ANTAGONISTS NEDERGAARD MAIKEN (US) 2005-10-26 EP disclosed
EP-1427404-A2 TREATMENT OF GLIAL TUMORS WITH GLUTAMATE ANTAGONISTS Nedergaard, Maiken (US) 2004-06-16 EP disclosed
WO-2003015713-A2 TREATMENT OF GLIAL TUMORS WITH GLUTAMATE ANTAGONISTS NEDERGAARD MAIKEN (US) 2003-02-27 WO disclosed