Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.44 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TGM2 | P21980 | 10/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL151622 | 0.93 | ZDHHC20 (0.50) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Lactic Acid SCHEMBL366893 | 0.84 | ZDHHC20 (0.46) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL5057278 | 0.81 | ZDHHC20 (0.47) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Lactic Acid SCHEMBL28232204 | 0.79 | ZDHHC20 (0.54) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL410374 | 0.79 | ZDHHC20 (0.52) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL20262206 | 0.77 | TSHR (0.52) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL19300353 | 0.76 | ZDHHC20 (0.48) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL28433367 | 0.76 | ZDHHC20 (0.48) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Acetic Acid SCHEMBL4158706 | 0.75 | ZDHHC20 (0.44) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL10751530 | 0.74 | ZDHHC20 (0.47) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041286-A1 | Systems, devices, and methods including implantable devices with anti-microbial properties | SEARETE LLC, A LIMITED LIABILITY CORPORATION OF THE STATE OF DELAWARE | 2012-02-16 | — | — | US | disclosed |
| US-20120041287-A1 | Systems, devices, and methods including implantable devices with anti-microbial properties | SEARETE LLC, A LIMITED LIABILITY CORPORATION OF THE STATE OF DELAWARE | 2012-02-16 | — | — | US | disclosed |