Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.46 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 7/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL28232204 | 0.88 | ZDHHC20 (0.54) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Acetic Acid SCHEMBL31500687 | 0.84 | ZDHHC20 (0.52) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL14966 | 0.84 | — | — | |
| SCHEMBL27729246 | 0.84 | ALDH1A1 (0.59) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Lactic Acid SCHEMBL613071 | 0.84 | ZDHHC20 (0.44) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Acrylic Acid SCHEMBL25395308 | 0.82 | ALDH1A1 (0.52) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL3058219 | 0.82 | — | — | |
| SCHEMBL28446965 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL28790325 | 0.82 | — | — | |
| Ethylene Glycol SCHEMBL28247245 | 0.82 | ALDH1A1 (0.56) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015034-A1 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT UTRECHT (NL) | 2012-01-19 | — | — | US | claimed |
| EP-1776400-B1 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT VAN UTRECHT (NL) | 2009-12-23 | — | — | EP | claimed |
| US-20080050435-A1 | Temperature Sensitive Polymers | CRISTAL DELIVERY B.V. (NL) | 2008-02-28 | — | — | US | claimed |
| EP-1776400-A2 | TEMPERATURE SENSITIVE POLYMERS | Universiteit van Utrecht (NL) | 2007-04-25 | — | — | EP | claimed |
| WO-2005087825-A2 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT UTRECHT (NL) | 2005-09-22 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080050435-A1 | Temperature Sensitive Polymers | LCT, LDHB, LDHA | ZDHHC20 1503/4885ZDHHC2 2499/4885TSHR 4210/4885 |
| US-20120015034-A1 | TEMPERATURE SENSITIVE POLYMERS | LCT, LDHA, LDHB | ZDHHC20 2972/4885ZDHHC2 3582/4885TSHR 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.