⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8473055 | 0.95 | PAOX (0.32) | — | |
| SCHEMBL8473054 | 0.95 | PAOX (0.32) | — | |
| SCHEMBL7122794 | 0.89 | — | — | |
| SCHEMBL8362130 | 0.77 | POLB (0.33) | — | |
| SCHEMBL8362134 | 0.77 | POLB (0.33) | — | |
| SCHEMBL6131578 | 0.74 | CYP2D6 (0.32) | — | |
| SCHEMBL8476517 | 0.72 | PAOX (0.38) | — | |
| SCHEMBL8476513 | 0.72 | PAOX (0.38) | — | |
| SCHEMBL6131544 | 0.71 | — | — | |
| SCHEMBL8476699 | 0.70 | PAOX (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958141-B2 | Rhenium and technetium complexes containing a hypoxia-localizing moiety | BRACCO INTERNATIONAL B.V. (NL) | 2005-10-25 | — | — | US | disclosed |
| US-20040191174-A1 | Rhenium and technetium complexes containing a hypoxia-localizing moiety | BRACCO SUISSE SA (CH) | 2004-09-30 | — | — | US | disclosed |
| US-6699458-B2 | CELL MEMBRANE PERMEABILITIES GREATER THAN THAT OF SUCROSE | BRACCO INTERNATIONAL B.V. (NL) | 2004-03-02 | — | — | US | disclosed |
| US-20040010127-A1 | RHENIUM AND TECHNETIUM COMPLEXES CONTAINING A HYPOXIA-LOCALIZING MOIETY | BRACCO SUISSE SA (CH) | 2004-01-15 | — | — | US | disclosed |
| US-6660246-B1 | 3,3,9,9-Tetramethyl-4,8-diazaundecane-2,10-dione 2-Hydrazone 10-Oxime; | BRACCO INTERNATIONAL, BV (NL) | 2003-12-09 | — | — | US | disclosed |
| US-20020054853-A1 | Rhenium and technetium complexes containing a hypoxia-localizing moiety | BRACCO SUISSE SA (CH) | 2002-05-09 | — | — | US | disclosed |
| US-6359120-B1 | REACTING ALKYLENE DIAMINE WITH HALOKETONE TO PROVIDE AN ALKYLENE DIAMINEDIKETONE WHICH IS CONVERTED TO ALKYLENE DIAMINEDIOXIME; OR REACTING ALKYLENE DIAMINE WITH FIRST HALOKETONE AND REACTING WITH SECOND HALOKETONE | BRACCO INTERNATIONAL B.V. (NL) | 2002-03-19 | — | — | US | disclosed |
| US-6184361-B1 | Rhenium and technetium complexes containing a hypoxia-localizing moiety | BRACCO INTERNATIONAL B.V. (NL) | 2001-02-06 | — | — | US | disclosed |
| US-5808091-A | DIAGNOSTIC IMAGING AGENT | BRACCO INTERNATIONAL B.V. | 1998-09-15 | — | — | US | disclosed |
| EP-0688313-B1 | LIGANDS AND METAL COMPLEXES THEREOF | BRACCO INT BV (NL) | 1998-04-08 | — | — | EP | disclosed |
| US-5688487-A | Diagnostic imaging methods using rhenium and technetium complexes containing a hypoxia-localizing moiety | BRACCO INTERNATIONAL B.V. (NL) | 1997-11-18 | — | — | US | disclosed |
| US-5663307-A | Hydrazone containing ligands and metal complexes thereof | BRACCO INTERNATIONAL B.V. | 1997-09-02 | — | — | US | disclosed |
| US-5651954-A | Method of using hydrazone containing ligands and metal complexes thereof | BRACCO INTERNATIONAL B.V. (NL) | 1997-07-29 | — | — | US | disclosed |
| EP-0544412-B1 | Rhenium and technetium complexes containing a hypoxia-localizing moiety | BRACCO INT BV (NL) | 1997-07-23 | — | — | EP | disclosed |
| US-5506345-A | ANTIHYPOXIC AGENTS | AMERSHAM INTERNATIONAL PLC (GB) | 1996-04-09 | — | — | US | disclosed |
| US-5387692-A | A bisamine oxime compound containing a 2-nitroimidazole group | AMERSHAM INTERNATIONAL PLC (GB) | 1995-02-07 | — | — | US | disclosed |
| EP-0544412-A2 | Rhenium and technetium complexes containing a hypoxia-localizing moiety | BRACCO INTERNATIONAL B.V. (NL) | 1993-06-02 | — | — | EP | disclosed |