Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ucb-1184197. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 known ✓ | P13612 | 20/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 20/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ucb-1184197 SCHEMBL3833843 | 1.00 | ITGB1 (0.47) | ITGB1ITGA4CYP3A4CYP2C9 | |
| Ucb-1184197 SCHEMBL29373839 | 1.00 | ITGB1 (0.47) | ITGB1ITGA4CYP3A4CYP2C9 | |
| SCHEMBL5573810 | 0.92 | ITGB1 (0.45) | ITGB1ITGA4CYP3A4CYP2C9 | |
| SCHEMBL3835521 | 0.91 | ITGB1 (0.46) | ITGB1ITGA4CYP3A4CYP2C9 | |
| Zaurategrast SCHEMBL5571298 | 0.90 | ITGB1 (0.56) | ITGB1ITGA4CYP3A4CYP2C9 | |
| Zaurategrast SCHEMBL2976322 | 0.90 | ITGB1 (0.56) | ITGB1ITGA4CYP3A4CYP2C9 | |
| SCHEMBL3836401 | 0.90 | ITGB1 (0.51) | ITGB1ITGA4CYP3A4CYP2C9 | |
| SCHEMBL3832796 | 0.87 | ITGB1 (0.47) | ITGB1ITGA4CYP3A4CYP2C9 | |
| SCHEMBL3836794 | 0.84 | ITGA4 (0.43) | ITGB1ITGA4CYP3A4CYP2C9 | |
| SCHEMBL2990251 | 0.83 | ITGB1 (0.56) | ITGB1ITGA4CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3875078-A1 | COMPOUNDS FOR THE TREATMENT OF COVID-19 | Dompe' Farmaceutici S.P.A. (IT) | 2021-09-08 | — | — | EP | claimed |
| EP-3884276-A2 | PREDICTING A TREATMENT RESPONSE IN INFLAMMATORY BOWEL DISEASE | Katholieke Universiteit Leuven (BE) | 2021-09-29 | — | — | EP | disclosed |
| EP-3875078-A1 | COMPOUNDS FOR THE TREATMENT OF COVID-19 | Dompe' Farmaceutici S.P.A. (IT) | 2021-09-08 | — | — | EP | disclosed |
| US-6951943-B2 | Process for the preparation of phenylalanine enamide derivatives | CELLTECH R & D LIMITED (GB) | 2005-10-04 | — | — | US | disclosed |
| US-20040073033-A1 | Process for the preparation of phenylalanine enamide derivatives | UCB PHARMA S.A. (BE) | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073033-A1 | Process for the preparation of phenylalanine enamide derivatives | NPY2R, NPY1R, NPR1 | ITGA4 3960/4885ITGB1 4148/4885CYP3A4 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.