Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22122844 | 0.82 | SMN1; SMN2 (0.44) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6819481 | 0.81 | TSHR (0.52) | PKMMAPTTSHRTNFSF11CYP3A4 | |
| SCHEMBL29089553 | 0.81 | KMT2A (0.48) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6132065 | 0.80 | PTPN11 (0.58) | MAPTPTPN11CYP3A4KMT2AKDM4E | |
| SCHEMBL15012676 | 0.79 | HTT (0.48) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL2171686 | 0.78 | LCK (0.43) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL30897207 | 0.78 | LCK (0.43) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7574341 | 0.78 | SMN1; SMN2 (0.48) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL30076482 | 0.78 | SMN1; SMN2 (0.48) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL13018859 | 0.77 | MEN1 (0.46) | PKMNPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214310-B1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1214310-A1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-6348604-B1 | COMPOUNDS IN WHICH SELECTION AND PLACEMENT OF SUBSTITUENTS CONTROL WAVELENGTH AND/OR INTENSITY OF VISIBLE ABSORBANCE BANDS | PPG INDUSTRIES OHIO, INC. | 2002-02-19 | — | — | US | disclosed |
| WO-2001019812-A1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-03-22 | — | — | WO | disclosed |