Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6815095 | 0.83 | CNR2 (0.54) | TSHRMAPTMAPK1CYP1A2CYP2C19 | |
| SCHEMBL6131966 | 0.81 | PKM (0.52) | TSHRMAPTCNR2CYP3A4KDM4E | |
| SCHEMBL6818862 | 0.81 | TUBB4A (0.50) | TSHRMAPTMAPK1CYP1A2CYP2C19 | |
| SCHEMBL18288083 | 0.78 | HPGD (0.53) | TSHRMAPTMAPK1CYP1A2CYP2C19 | |
| SCHEMBL6345952 | 0.76 | HPGD (0.62) | TSHRMAPTCYP1A2CYP2C19HPGD | |
| SCHEMBL7995114 | 0.75 | TNFSF11 (0.61) | TSHRMAPTHPGDKDM4ERECQL | |
| SCHEMBL6611954 | 0.75 | MAPT (0.63) | TSHRMAPTMAPK1CYP1A2CYP2C19 | |
| SCHEMBL1333620 | 0.74 | CYP1A2 (0.81) | TSHRMAPTCYP1A2CYP2C19HPGD | |
| SCHEMBL2450750 | 0.74 | TUBB4A (0.72) | CYP1A2CYP2C19HPGDCYP2D6ALDH1A1 | |
| SCHEMBL9343741 | 0.74 | CA12 (0.63) | TSHRMAPTMAPK1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214311-B1 | NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-1214311-A1 | NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-6296785-B1 | OPHTHALMIC AND CONTACT LENSES; WINDOWS, SAFETY GLASS FOR CARS | PPG INDUSTRIES OHIO, INC. | 2001-10-02 | — | — | US | disclosed |
| WO-2001019813-A1 | NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-03-22 | — | — | WO | disclosed |