Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 12/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.35 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134324 | 0.89 | ADORA1 (0.47) | ADORA1ADORA2AKMT2AADORA2B | |
| SCHEMBL6134159 | 0.88 | RPS6KA3 (0.46) | ADORA1ADORA2AKMT2AADORA2BBMPR1B | |
| SCHEMBL6133581 | 0.88 | ADORA1 (0.49) | ADORA1ADORA2AKMT2AADORA2BBMPR1B | |
| SCHEMBL6134103 | 0.88 | PIK3CD (0.46) | ADORA1ADORA2AADORA2BBMPR1BBMPR1A | |
| SCHEMBL6133386 | 0.87 | KMT2A (0.40) | ADORA1ADORA2AKMT2AADORA2BBMPR1B | |
| SCHEMBL6134450 | 0.87 | ADORA1 (0.50) | ADORA1ADORA2AKMT2AADORA2BBMPR1B | |
| SCHEMBL6134188 | 0.87 | LMNA (0.45) | ADORA1ADORA2AKMT2AADORA2BBMPR1B | |
| SCHEMBL6133461 | 0.87 | ADORA1 (0.43) | ADORA1ADORA2ACDK5CDK5R1KMT2A | |
| SCHEMBL6134060 | 0.85 | RET (0.38) | ADORA1ADORA2AKMT2AADORA2BBMPR1B | |
| SCHEMBL6133595 | 0.85 | KMT2A (0.58) | ADORA1ADORA2AKMT2AHRH3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ADORA2A 2/4885CDK5 823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.