Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 13/20 | 0.44 |
| ▸ | CASP1 | P29466 | 13/20 | 0.44 |
| ▸ | CASP7 | P55210 | 13/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | GLA | P06280 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133753 | 0.88 | TP53 (0.38) | ALDH1A1CYP1A2CASP1CASP7HIF1A | |
| SCHEMBL6134738 | 0.85 | ADORA3 (0.39) | ALDH1A1CASP7HSD17B10TP53MEN1 | |
| SCHEMBL6134324 | 0.84 | ADORA1 (0.47) | KMT2A | |
| SCHEMBL6133995 | 0.82 | TP53 (0.38) | ALDH1A1GLATP53MEN1KMT2A | |
| SCHEMBL6134094 | 0.82 | NTRK1 (0.44) | TP53MEN1KMT2ANPSR1MERTK | |
| SCHEMBL6135183 | 0.82 | MERTK (0.42) | TP53KDM4EPOLBNUDT1MERTK | |
| SCHEMBL6134384 | 0.81 | KMT2A (0.40) | ALDH1A1CYP1A2CASP1CASP7HIF1A | |
| SCHEMBL6134200 | 0.81 | POLB (0.39) | ALDH1A1CYP1A2CASP1CASP7HIF1A | |
| SCHEMBL6134812 | 0.80 | MERTK (0.56) | CYP1A2CASP1CASP7HIF1ACYP2C9 | |
| SCHEMBL6133535 | 0.80 | MERTK (0.34) | CYP1A2TP53CYP3A4TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
| WO-2003057689-A1 | AMINOPYRIMIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | ALDH1A1 801/4885CYP1A2 1170/4885CASP1 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.