Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.37 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.32 |
| ▸ | SRC | P12931 | 4/20 | 0.32 |
| ▸ | ABL1 | P00519 | 3/20 | 0.32 |
| ▸ | HCK | P08631 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133736 | 0.88 | ADORA2A (0.41) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL6133778 | 0.88 | ADORA2A (0.42) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL6134761 | 0.86 | BMPR1B (0.33) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL6133695 | 0.86 | IKBKB (0.37) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL6134202 | 0.85 | PIK3CA (0.35) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL6133555 | 0.79 | ADORA2A (0.41) | ADORA1ADORA2A | |
| SCHEMBL6134309 | 0.78 | ADORA2A (0.41) | ADORA1ADORA2A | |
| SCHEMBL6134113 | 0.78 | ADORA2A (0.43) | HRH3ADORA1ADORA2A | |
| SCHEMBL6133889 | 0.78 | ADORA2A (0.42) | ADORA1ADORA2A | |
| SCHEMBL6133772 | 0.77 | ADORA2A (0.40) | HRH3ADORA1ADORA2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
| WO-2003057689-A1 | AMINOPYRIMIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | MTOR 1987/4885PIK3CA 1111/4885RICTOR 2862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.