Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133991 | 0.96 | SRC (0.43) | DHFRADORA2AADORA1SRCABL1 | |
| SCHEMBL6133797 | 0.94 | ADORA1 (0.43) | DHFRADORA2AADORA1SRCABL1 | |
| SCHEMBL6133501 | 0.90 | ADORA1 (0.41) | DHFRADORA2AADORA1SRCABL1 | |
| SCHEMBL6135106 | 0.90 | LMNA (0.45) | DHFRADORA2AADORA1SRCABL1 | |
| SCHEMBL6135205 | 0.89 | ADORA1 (0.44) | ADORA2AADORA1SRCABL1HRH3 | |
| SCHEMBL6133860 | 0.89 | ADORA1 (0.42) | ADORA2AADORA1SRCABL1HRH3 | |
| SCHEMBL6134416 | 0.89 | ADORA1 (0.42) | ADORA2AADORA1SRCABL1HRH3 | |
| SCHEMBL6133451 | 0.89 | HRH3 (0.45) | SRCABL1HRH3 | |
| SCHEMBL6133628 | 0.88 | ADORA2A (0.47) | ADORA2AADORA1 | |
| SCHEMBL6133511 | 0.87 | ADORA1 (0.43) | ADORA2AADORA1SRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
| WO-2003057689-A1 | AMINOPYRIMIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | DHFR 146/4885ADORA2A 2/4885ADORA1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.