Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.35 |
| ▸ | PDE1A | P54750 | 5/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.35 |
| ▸ | PDE5A | O76074 | 4/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134784 | 0.92 | PDE1A (0.38) | LRRK2LMNAADORA2AADORA1MEN1 | |
| SCHEMBL6133847 | 0.91 | LRRK2 (0.39) | LRRK2LMNAGAAMAPK10ADORA2A | |
| SCHEMBL6133515 | 0.91 | CHRNA7 (0.38) | LRRK2LMNAADORA2AADORA1MAPT | |
| SCHEMBL6133855 | 0.90 | ADORA2A (0.48) | LRRK2LMNAADORA2AADORA1MAPT | |
| SCHEMBL6134869 | 0.89 | PDE5A (0.37) | LRRK2LMNAADORA2AADORA1MEN1 | |
| SCHEMBL6134700 | 0.89 | IDO1 (0.40) | LRRK2LMNAADORA2AADORA1MAPT | |
| SCHEMBL6133823 | 0.89 | ADORA1 (0.35) | LRRK2LMNAADORA2AADORA1MAPT | |
| SCHEMBL6135805 | 0.89 | ADORA1 (0.37) | LRRK2LMNAADORA2AADORA1MAPT | |
| SCHEMBL6134186 | 0.88 | ADORA1 (0.34) | LRRK2LMNAADORA2AADORA1KMT2A | |
| SCHEMBL6135333 | 0.88 | HTR7 (0.39) | LRRK2ADORA2AADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
| WO-2003057689-A1 | AMINOPYRIMIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | LRRK2 225/4885LMNA 3549/4885GAA 2324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.