Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 6/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133988 | 0.87 | ADORA2A (0.40) | ADORA2AADORA2BADORA1CDK5CDK5R1 | |
| SCHEMBL6134686 | 0.86 | GFER (0.43) | ADORA2AADORA2BADORA1MAPTKMT2A | |
| SCHEMBL6133826 | 0.85 | CLK1 (0.36) | ADORA2AADORA2BADORA1CLK1CDK5 | |
| SCHEMBL6133471 | 0.84 | ADORA1 (0.50) | ADORA2AADORA2BADORA1KMT2A | |
| SCHEMBL6134495 | 0.84 | ADORA2A (0.48) | ADORA2AADORA2BADORA1ALDH1A1BRD4 | |
| SCHEMBL6134279 | 0.82 | CLK1 (0.34) | ADORA2AADORA2BADORA1CLK1CDK5 | |
| SCHEMBL6134537 | 0.78 | RPS6KA3 (0.48) | ADORA2AADORA2BADORA1KMT2A | |
| SCHEMBL6133620 | 0.78 | ADORA1 (0.52) | ADORA2AADORA2BADORA1MEN1MAPT | |
| SCHEMBL6134282 | 0.78 | ADORA2A (0.43) | ADORA2AADORA2BADORA1KDM4EALDH1A1 | |
| SCHEMBL6134083 | 0.78 | ADORA2A (0.65) | ADORA2AADORA2BADORA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | ADORA2A 2/4885ADORA2B 1/4885ADORA1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.