Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4579770 | 0.89 | POLB (0.61) | POLBHTR2AHTR2CHTR2BTSHR | |
| SCHEMBL6134745 | 0.87 | CHKA (0.50) | POLBTSHRLSSHDAC6MAPT | |
| SCHEMBL5632521 | 0.84 | POLB (0.54) | POLBHTR2AHTR2CHTR2BITGB3 | |
| SCHEMBL15853641 | 0.81 | LSS (0.64) | POLBTSHRLSSMAPK1SMN1; SMN2 | |
| SCHEMBL7340640 | 0.79 | CSNK2A2 (0.54) | TSHRHDAC6MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL6373109 | 0.79 | NPC1 (0.58) | TSHRMAPTCHEK1ALDH1A1CSNK2A2 | |
| SCHEMBL6235038 | 0.79 | CSNK2A2 (0.46) | HTR2AHTR2CHTR2BTSHRCHEK1 | |
| SCHEMBL6134965 | 0.79 | NPC1 (0.47) | POLBHTR2AHTR2CHTR2BTSHR | |
| SCHEMBL6700832 | 0.78 | POLB (0.60) | POLBHTR2AHTR2CHTR2BITGB3 | |
| SCHEMBL6132526 | 0.78 | CSNK2A2 (0.45) | HTR2AHTR2CHTR2BTSHRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261177-A1 | Compound | ASTELLAS PHARMA INC. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261177-A1 | Compound | MANBA, MAN2B1, MAN2A1 | POLB 1754/4885HTR2A 4868/4885HTR2C 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.