Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134818 | 0.87 | POLB (0.51) | POLBTSHRMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5633970 | 0.85 | CHKA (0.56) | CHKAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL6133671 | 0.85 | MAPT (0.53) | CHKAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL13244604 | 0.81 | SMN1; SMN2 (0.65) | CHKATSHRMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL7339724 | 0.81 | ALDH1A1 (0.52) | TSHRMAPTALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL6134965 | 0.81 | NPC1 (0.47) | POLBTSHRALDH1A1SMN1; SMN2HDAC6 | |
| SCHEMBL6376053 | 0.81 | RAB9A (0.56) | POLBTSHRMAPTALDH1A1USP2 | |
| SCHEMBL6241221 | 0.80 | USP2 (0.46) | CHKAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL6132282 | 0.80 | PDE4D (0.46) | CHKAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL6134614 | 0.80 | DRD3 (0.47) | POLBTSHRMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261177-A1 | Compound | ASTELLAS PHARMA INC. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261177-A1 | Compound | MANBA, MAN2B1, MAN2A1 | CHKA 2357/4885POLB 1754/4885TSHR 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.