Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133388 | 0.91 | ADORA1 (0.57) | ADORA1KDM4EADORA2AKMT2AMAPK1 | |
| SCHEMBL6134037 | 0.88 | RPS6KA3 (0.45) | ADORA1ALDH1A1ADORA2AHRH3TLR7 | |
| SCHEMBL6134870 | 0.87 | ADORA1 (0.43) | ADORA1ALDH1A1KDM4EADORA2AKMT2A | |
| SCHEMBL6134316 | 0.86 | HRH3 (0.43) | ALDH1A1KDM4EHRH3KMT2AMEN1 | |
| SCHEMBL6133989 | 0.83 | KMT2A (0.62) | ADORA1ALDH1A1KDM4EADORA2AHRH3 | |
| SCHEMBL6133447 | 0.81 | ADORA2A (0.60) | ADORA1ADORA2AHRH3KMT2ANPC1 | |
| SCHEMBL6134194 | 0.81 | ADORA1 (0.43) | ADORA1ALDH1A1ADORA2A | |
| SCHEMBL6133660 | 0.80 | PDE4A (0.49) | ADORA1ALDH1A1KDM4EADORA2AKMT2A | |
| SCHEMBL6134043 | 0.80 | ADORA1 (0.53) | ADORA1ADORA2AHRH3KMT2ANPC1 | |
| SCHEMBL6134177 | 0.80 | ADORA1 (0.50) | ADORA1ALDH1A1KDM4EADORA2ATLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
| WO-2003057689-A1 | AMINOPYRIMIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ALDH1A1 801/4885KDM4E 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.