Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 6/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134829 | 0.91 | ADORA1 (0.46) | ADORA1ADORA2AFGFR1FGFR2FGFR3 | |
| SCHEMBL6133497 | 0.86 | ADORA1 (0.54) | ADORA1ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL6133989 | 0.85 | KMT2A (0.62) | ADORA1ADORA2AKMT2AKDM4EMAPT | |
| SCHEMBL6133447 | 0.84 | ADORA2A (0.60) | ADORA1ADORA2AFGFR1FGFR2FGFR3 | |
| SCHEMBL6134043 | 0.82 | ADORA1 (0.53) | ADORA1ADORA2AFGFR1FGFR2FGFR3 | |
| SCHEMBL6134495 | 0.82 | ADORA2A (0.48) | ADORA1ADORA2AFGFR1MAPTNPSR1 | |
| SCHEMBL6134037 | 0.82 | RPS6KA3 (0.45) | ADORA1ADORA2AKMT2AADORA2B | |
| SCHEMBL6134537 | 0.82 | RPS6KA3 (0.48) | ADORA1ADORA2AKMT2AADORA2B | |
| SCHEMBL6133620 | 0.82 | ADORA1 (0.52) | ADORA1ADORA2AKMT2AMAPTMAPK1 | |
| SCHEMBL6134360 | 0.81 | LMNA (0.47) | ADORA1ADORA2AKMT2AKDM4EADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ADORA2A 2/4885PDE4A 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.