Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | NAAA | Q02083 | 1/20 | 0.62 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | DGKA | P23743 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PAM | P19021 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6380882 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL2269645 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL7780438 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL5153816 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL10626588 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL580166 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL972977 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL410582 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL2763091 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA | |
| SCHEMBL27505167 | 0.94 | HTR2C (0.70) | HTR2CNAAARAD52NPSR1DGKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506168-A2 | GELLING AGENTS | Applied NanoSystems B.V. (NL) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097587-A2 | GELLING AGENTS | APPLIED NANOSYSTEMS B.V. (NL) | 2003-11-27 | — | — | WO | disclosed |