SCHEMBL6135956

SCHEMBL6135956

CN(CCN(C)C(=O)C1=NCCO1)C(=O)C1=NCCO1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 2/20 0.34
HDAC3 O15379 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34
PIK3CA P42336 2/20 0.30
MTOR P42345 2/20 0.30
PIK3CG P48736 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6136100 0.93 HDAC3 (0.35) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL11224284 0.89 HDAC3 (0.34) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL11119977 0.82 HDAC3 (0.33) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL11126797 0.77 HTT (0.41) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL13154302 0.73
SCHEMBL8915493 0.72
SCHEMBL25181753 0.72 HDAC3 (0.36) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL11119998 0.71 NOS3 (0.39)
SCHEMBL29232743 0.71 HDAC3 (0.47) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL11125564 0.70 HDAC3 (0.33) HDAC4HDAC3HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0737231-B2 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INC (KR) 2005-11-02 EP disclosed
EP-0737231-B1 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INC (KR) 2000-03-08 EP disclosed
US-5849820-A Thermal stabilized resin compositions KOLON INDUSTRIES, INC. (KR) 1998-12-15 US disclosed
EP-0737231-A1 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INDUSTRIES, INC. (KR) 1996-10-16 EP disclosed
WO-1995018181-A1 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INDUSTRIES, INC. (KR) 1995-07-06 WO disclosed
US-4331800-A CHAIN EXTENSION WITH A BIS/CYCLIC IMINOETHER TEIJIN LIMITED (JP) 1982-05-25 US disclosed
EP-0020944-A1 Process for producing aromatic polyesters having an increased degree of polymerisation, these aromatic polyesters, process for producing molded articles composed thereof, and these molded articles TEIJIN LIMITED (JP) 1981-01-07 EP disclosed