SCHEMBL6135958

SCHEMBL6135958

Cc1ccc2nn(-c3ccccc3O)nc2c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.71
RAB9A P51151 7/20 0.71
LMNA P02545 1/20 0.71
POLB P06746 3/20 0.50
ALDH1A1 P00352 8/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
KDM4E B2RXH2 7/20 0.47
NQO2 P16083 1/20 0.43
HPGD P15428 6/20 0.41
MAPT P10636 5/20 0.41
HSD17B10 Q99714 4/20 0.41
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
CASP1 P29466 3/20 0.41
TP53 P04637 2/20 0.41
CASP7 P55210 2/20 0.41
GAA P10253 1/20 0.41
ALOX15 P16050 2/20 0.41
APAF1 O14727 1/20 0.41
TDP1 Q9NUW8 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Drometrizole SCHEMBL7796640 0.89 NPC1 (0.90) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL3297579 0.86 NPC1 (0.81) NPC1RAB9ALMNAPOLBALDH1A1
Drometrizole SCHEMBL6667186 0.83 NPC1 (0.80) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL5471102 0.83 POLB (0.53) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL29422754 0.83 NPC1 (0.75) NPC1RAB9ALMNAPOLBALDH1A1
Drometrizole SCHEMBL15616 0.83 NPC1 (1.00) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL906023 0.83 NPC1 (0.75) NPC1RAB9ALMNAPOLBALDH1A1
Drometrizole SCHEMBL2548258 0.83 NPC1 (1.00) NPC1RAB9ALMNAPOLBALDH1A1
Drometrizole SCHEMBL29350665 0.83 NPC1 (1.00) NPC1RAB9ALMNAPOLBALDH1A1
Drometrizole SCHEMBL27755727 0.83 NPC1 (1.00) NPC1RAB9ALMNAPOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2740771-B1 COMPOSITE POWDER AND METHOD FOR PRODUCING SAME SAKAI CHEMICAL INDUSTRY CO (JP) 2023-07-19 EP disclosed
EP-3773436-B1 USE OF SORBITYL POLYRHAMNOSIDES AS HUMAN SKIN LIGHTENING AGENTS SOC DEXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) 2022-06-01 EP disclosed
EP-3723720-B1 NEW POLYOL POLYRHAMNOSIDES, PROCESS FOR THE PREPARATION THEREOF, AND COSMETIC AND/OR PHARMACEUTICAL COMPOSITION COMPRISING SAME SOC DEXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) 2022-01-05 EP disclosed
US-11179303-B2 Granular composite containing keratin and hexagonal plate-like zinc oxide SAKAI CHEMICAL INDUSTRY CO., LTD. (JP) 2021-11-23 US disclosed
EP-3723719-B1 NEW GLYCERYL POLYRHAMNOSIDES, PROCESS FOR THE PREPARATION THEREOF, AND COSMETIC AND/OR PHARMACEUTICAL COMPOSITION COMPRISING SAME SOC DEXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) 2021-10-20 EP disclosed
EP-3773436-A1 USE OF SORBITYL POLYRHAMNOSIDES AS HUMAN SKIN LIGHTENING AGENTS Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC (FR) 2021-02-17 EP disclosed
EP-3773931-A1 NOVEL COMPOSITION BASED ON POLYCAFFEOYLQUINIC ACIDS, THE USE THEREOF IN COSMETICS AND COSMETIC COMPOSITIONS COMPRISING SAME Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC (FR) 2021-02-17 EP disclosed
US-20200368124-A1 GRANULAR COMPOSITE CONTAINING KERATIN AND HEXAGONAL PLATE-LIKE ZINC OXIDE SAKAI CHEMICAL INDUSTRY CO., LTD. (JP) 2020-11-26 US disclosed
EP-3723712-A1 NEW ALKYL POLYRHAMNOSIDES, PROCESS FOR THE PREPARATION THEREOF, AND COSMETIC AND/OR PHARMACEUTICAL COMPOSITION COMPRISING SAME Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC (FR) 2020-10-21 EP disclosed
EP-3723720-A1 NEW POLYOL POLYRHAMNOSIDES, PROCESS FOR THE PREPARATION THEREOF, AND COSMETIC AND/OR PHARMACEUTICAL COMPOSITION COMPRISING SAME Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC (FR) 2020-10-21 EP disclosed
US-7419513-B2 Hindered amine light stabilizers (HALS); for thermoset/thermoplastic resins, photographic applications, pigmented/dyed polypropylene, polyamide/polyester fibers, and for white, dyed, dipped, unscented/scented candle wax against discoloration and fading CIBA SPECIALTY CHEMICALS CORPORATION (US) 2008-09-02 US disclosed
EP-0846461-B1 OIL-IN-WATER EMULSION COMPOSITION AND OIL-IN-WATER EMULSIFIER SHISEIDO CO LTD (JP) 2005-11-02 EP disclosed
EP-0846708-B1 Photochromic resin compositions INNOTECH INC (US) 2002-10-09 EP disclosed
US-6074652-A MIXTURE OF AN MONOALKYL GLYCERYL ETHER, WAX AND SILICONE OIL SHISEIDO CO., LTD. (JP) 2000-06-13 US disclosed
US-5914174-A Lens or semi-finished blank comprising photochromic resin compositions INNOTECH, INC. (US) 1999-06-22 US disclosed
EP-0570230-B1 External preparation for skin SHISEIDO CO LTD (JP) 1998-09-30 EP disclosed
EP-0846461-A1 OIL-IN-WATER EMULSION COMPOSITION AND OIL-IN-WATER EMULSIFIER SHISEIDO COMPANY LIMITED (JP) 1998-06-10 EP disclosed
EP-0846708-A2 Photochromic resin compositions INNOTECH, Inc. (US) 1998-06-10 EP disclosed
US-5580549-A BLEACHING; 2-HYDROXYBENZOIC ACID COMPOUND SHISEIDO CO., LTD. (JP) 1996-12-03 US disclosed
EP-0570230-A1 External preparation for skin SHISEIDO COMPANY LIMITED (JP) 1993-11-18 EP disclosed