Drometrizole

Drometrizole

SCHEMBL7796640

Cc1ccc(O)c(-n2nc3ccccc3n2)c1.Oc1ccccc1-n1nc2ccccc2n1

nearest known ligand 0.90

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 8/20 0.90
RAB9A P51151 8/20 0.90
LMNA P02545 1/20 0.90
ALDH1A1 P00352 6/20 0.54
SMN1; SMN2 Q16637 5/20 0.54
KDM4E B2RXH2 4/20 0.52
POLB P06746 3/20 0.49
MAPT P10636 5/20 0.45
HPGD P15428 4/20 0.45
TDP1 Q9NUW8 2/20 0.45
NPSR1 Q6W5P4 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CYP1A2 P05177 2/20 0.41
IGF2BP2 Q9Y6M1 1/20 0.41
THRB P10828 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
MEN1 O00255 1/20 0.39
GAA P10253 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Drometrizole SCHEMBL27755727 0.95 NPC1 (1.00) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
Drometrizole SCHEMBL15616 0.95 NPC1 (1.00) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
Drometrizole SCHEMBL29350665 0.95 NPC1 (1.00) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
Drometrizole SCHEMBL2548258 0.95 NPC1 (1.00) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
Drometrizole SCHEMBL6667186 0.94 NPC1 (0.80) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
Drometrizole SCHEMBL3793068 0.89 NPC1 (0.88) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
Drometrizole SCHEMBL890036 0.89 NPC1 (0.88) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
Drometrizole SCHEMBL6664698 0.89 NPC1 (0.88) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL6135958 0.89 NPC1 (0.71) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL906023 0.85 NPC1 (0.75) NPC1RAB9ALMNAALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023166983-A1 PHOSPHITE ESTER COMPOSITION 住友化学株式会社 2023-09-07 WO disclosed
WO-2023166978-A1 PROCESS STABILIZER, ORGANIC MATERIAL COMPOSITION, AND METHOD FOR STABILIZING ORGANIC MATERIAL 住友化学株式会社 2023-09-07 WO disclosed
WO-2023286616-A1 PHENOLIC COMPOUND, ORGANIC MATERIAL STABILIZER, RESIN COMPOSITION, AND METHOD FOR STABILIZING ORGANIC MATERIAL 住友化学株式会社 2023-01-19 WO disclosed
WO-2022255116-A1 PHOSPHITE ESTER COMPOSITION 住友化学株式会社 2022-12-08 WO disclosed
EP-0823435-B1 Phosphites, process for producing the same and their use SUMITOMO CHEMICAL CO (JP) 2001-11-21 EP disclosed
EP-0823435-A2 Phosphites, process for producing the same and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-02-11 EP disclosed
US-4319016-A Ultraviolet-absorbing amino compound and method of making KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 1982-03-09 US disclosed