SCHEMBL6135979

SCHEMBL6135979

Cc1cc(C(=O)O)ccc1CBr

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.51
TSHR P16473 3/20 0.47
MYC P01106 1/20 0.47
ESR1 P03372 1/20 0.47
ALOX15 P16050 1/20 0.47
PTPN7 P35236 1/20 0.47
HSD17B10 Q99714 1/20 0.47
GRM1 Q13255 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
KMT2A Q03164 1/20 0.46
ACE2 Q9BYF1 2/20 0.44
RXRA P19793 2/20 0.43
ALDH1A1 P00352 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
KDM4E B2RXH2 2/20 0.43
GAA P10253 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
NR1H4 Q96RI1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27311828 0.85 EPHX2 (0.49) EPHX2TSHRMYCESR1ALOX15
SCHEMBL7968434 0.85 MRGPRX4 (0.49) EPHX2TSHRMYCESR1ALOX15
SCHEMBL16769474 0.85 PKM (0.46) HSD17B10TDP1KMT2AALDH1A1SMN1; SMN2
SCHEMBL2591830 0.84 EPHX2 (0.54) EPHX2TSHRMYCESR1ALOX15
SCHEMBL6859659 0.84 EPHX2 (0.54) EPHX2TSHRMYCESR1ALOX15
SCHEMBL4549023 0.82 ACE2 (0.53) EPHX2TSHRMYCESR1ALOX15
SCHEMBL3980824 0.82 TSHR (0.46) TSHRACE2ALDH1A1KDM4EGAA
SCHEMBL30028599 0.82 TSHR (0.46) TSHRACE2ALDH1A1KDM4EGAA
SCHEMBL2538201 0.81 EPHX2 (0.49) EPHX2TSHRMYCESR1ALOX15
SCHEMBL3536952 0.81 EPHX2 (0.51) EPHX2TSHRMYCESR1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108084077-B Synthetic method of zafirlukast intermediate 江汉大学 2020-04-14 CN claimed
CN-105884758-A Tricyclic compound and application thereof to drugs 广东东阳光药业有限公司 2016-08-24 CN disclosed
EP-0777492-B1 COMBINATORIAL LIBRARIES OF SUBSTRATE-BOUND CYCLIC ORGANIC COMPOUNDS CHIRON CORP (US) 2005-01-19 EP disclosed
CN-1433415-A N-[5-[[[5-alkyl-2-oxazlyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases BRISTOL MYERS SQUIBB CO (US) 2003-07-30 CN disclosed
EP-0777492-A4 COMBINATORIAL LIBRARIES OF SUBSTRATE-BOUND CYCLIC ORGANIC COMPOUNDS CHIRON CORP (US) 2002-11-27 EP disclosed
US-5958792-A DERIVATIZING SOLID SUPPORT SURFACES WITH A GROUP CONSISTING OF O AND NH TO PROVIDE PLURALITY OF DERIVATIZED SUPPORT SURFACES, DIVIDING THEM INTO SUBAMOUNTS, REACTING DIFFERENT SUBMONOMER WITH ACTIVE GROUP OF SUBAMOUNT, RECOMBINING CHIRON CORPORATION (US) 1999-09-28 US disclosed
EP-0777492-A1 COMBINATORIAL LIBRARIES OF SUBSTRATE-BOUND CYCLIC ORGANIC COMPOUNDS CHIRON CORPORATION (US) 1997-06-11 EP disclosed
WO-1996040201-A1 COMBINATORIAL LIBRARIES OF SUBSTRATE-BOUND CYCLIC ORGANIC COMPOUNDS CHIRON CORPORATION (US) 1996-12-19 WO disclosed