Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 1/20 | 0.78 |
| ▸ | SELP | P16109 | 2/20 | 0.60 |
| ▸ | SELE | P16581 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | SELL | P14151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30557308 | 1.00 | HPSE (0.78) | HPSESELPSELEEPHX2TP53 | |
| SCHEMBL11628807 | 0.87 | HPSE (0.65) | HPSESELPSELESMN1; SMN2MEN1 | |
| SCHEMBL7387069 | 0.85 | DDX3X (0.71) | HPSEMEN1KMT2ANR1H4NPC1 | |
| SCHEMBL7251772 | 0.85 | RAB9A (0.66) | HPSESELPSELESMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL11628069 | 0.85 | HPSE (0.63) | HPSESELPSELESMN1; SMN2MEN1 | |
| SCHEMBL30802742 | 0.84 | SMN1; SMN2 (0.61) | HPSEEPHX2TP53EPHX1TSHR | |
| SCHEMBL27954484 | 0.84 | SMN1; SMN2 (0.61) | HPSEEPHX2TP53EPHX1TSHR | |
| SCHEMBL11630238 | 0.84 | HPSE (0.62) | HPSESELPSELESMN1; SMN2MEN1 | |
| SCHEMBL5151866 | 0.84 | KMT2A (0.74) | HPSEEPHX2TP53EPHX1TSHR | |
| SCHEMBL11628800 | 0.84 | HPSE (0.61) | HPSESELPSELEEPHX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042279-B1 | SUBSTITUTED BETA-ALANINES | AVENTIS PHARMA LTD (GB) | 2005-03-02 | — | — | EP | disclosed |
| US-6352977-B1 | ALANINE WITH PRODRUGS | AVENTIS PHARMA LIMITED (GB) | 2002-03-05 | — | — | US | disclosed |
| EP-1042279-A1 | SUBSTITUTED BETA-ALANINES | Aventis Pharma Limited (GB) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033789-A1 | SUBSTITUTED β-ALANINES | AVENTIS PHARMA LIMITED (GB) | 1999-07-08 | — | — | WO | disclosed |